Ferroxidase-like activity of au nanorod/pt nanodot structures and implications for cellular oxidative stress
文献类型：期刊论文
| 作者 | Liu, Jianbo1,2; Jiang, Xiumei3; Wang, Liming3; Hu, Zhijian1; Wen, Tao1,4; Liu, Wenqi1; Yin, Junjie4; Chen, Chunying3; Wu, Xiaochun1 |
| 刊名 | Nano research
 |
| 出版日期 | 2015-12-01 |
| 卷号 | 8期号:12页码:4024-4037 |
| 关键词 | Au@pt nanostructure Ferroxidase Peroxidase Antioxidant activity Biological effect |
| ISSN号 | 1998-0124 |
| DOI | 10.1007/s12274-015-0904-x |
| 通讯作者 | Yin, junjie(junjie.yin@fda.hhs.gov) |
| 英文摘要 | Platinum nanoparticles (nps) are reported to mimic various antioxidant enzymes and thus may produce a positive biological effect by reducing reactive oxygen species (ros) levels. in this manuscript, we report pt nps as an enzyme mimic of ferroxidase by depositing platinum nanodots on gold nanorods (au@pt ndrs). au@pt ndrs show ph-dependent ferroxidase-like activity and have higher activity at neutral ph values. cytotoxicity results with human cell lines (lung adenocarcinoma a549 and normal bronchial epithelial cell line hbe) show that au@pt ndrs are taken up into cells via endocytosis and translocate into the endosome/lysosome. au@pt ndrs have good biocompatibility at ndr particle concentrations lower than 0.15 nie. however, in the presence of h2o2, lysosomelocated ndrs exhibit peroxidase-like activity and therefore increase cytotoxicity. in the presence of fe2+, the ferroxidase-like activity of the ndrs protects cells from oxidative stress by consuming h2o2. thorough consideration should be given to this behavior when employing au@pt ndrs in biological systems. |
| WOS关键词 | PEROXIDASE-LIKE ACTIVITY ; ENZYME-LIKE ACTIVITIES ; AT-PT NANOSTRUCTURES ; ARTIFICIAL ENZYMES ; PLATINUM NANOPARTICLES ; COLORIMETRIC DETECTION ; CATALYTIC-ACTIVITY ; SUPEROXIDE ANION ; IRON-METABOLISM ; GRAPHENE OXIDE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000367003400027 |
| 出版者 | TSINGHUA UNIV PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176432 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yin, Junjie |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Standardizat & Measurement Nanotechnol, Beijing 100190, Peoples R China 2.Zaozhuang Univ, Coll Optoelect Engn, Zaozhuang 277100, Peoples R China 3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.US FDA, Div Analyt Chem, Off Regulatory Sci, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA |
| 推荐引用方式 GB/T 7714 | Liu, Jianbo,Jiang, Xiumei,Wang, Liming,et al. Ferroxidase-like activity of au nanorod/pt nanodot structures and implications for cellular oxidative stress[J]. Nano research,2015,8(12):4024-4037. |
| APA | Liu, Jianbo.,Jiang, Xiumei.,Wang, Liming.,Hu, Zhijian.,Wen, Tao.,...&Wu, Xiaochun.(2015).Ferroxidase-like activity of au nanorod/pt nanodot structures and implications for cellular oxidative stress.Nano research,8(12),4024-4037. |
| MLA | Liu, Jianbo,et al."Ferroxidase-like activity of au nanorod/pt nanodot structures and implications for cellular oxidative stress".Nano research 8.12(2015):4024-4037. |
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