Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect
文献类型：期刊论文
| 作者 | Ling, Ya1; Gao, Yuan2; Shu, Chang1; Zhou, Ying1; Zhong, Wenying1,3; Xu, Bing4 |
| 刊名 | Rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:123页码:101475-101479 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c5ra14156g |
| 通讯作者 | Zhong, wenying(wyzhong@cpu.edu.cn) |
| 英文摘要 | Doxorubicin (dox) and taxol can be covalently bonded to the same peptide segment via proper structural modification. doxorubicin-maleimide derivative links to peptide via michael addition reaction and taxol-succi-nhs active ester connects to the same peptide backbone through ester-amide exchange reaction. enzymatic transformation, as an inherent biological process, is applied here to trigger the formation of nanofiber networks from the as prepared hydrogelator precursor. the precursor which loads equal molar ratio of dox and taxol can self-assemble to form a red stable hydrogel after dephosphorylation reaction catalyzed by alkaline phosphatase (alp). this hydrogel could maintain sustained release of drugs and show strong anticancer effect. this work, as a new strategy to build a codelivery system of covalently linked dox and taxol, owns the potential to serve as an injectable hydrogel for therapeutic applications. |
| WOS关键词 | METASTATIC BREAST-CANCER ; CO-DELIVERY ; ANTITUMOR EFFICACY ; IN-VITRO ; PACLITAXEL ; HYDROGELS ; INHIBITION ; NANOPARTICLES ; STABILITY ; SYSTEM |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000365952200031 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176436 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhong, Wenying |
| 作者单位 | 1.China Pharmaceut Univ, Dept Analyt Chem, Nanjing, Jiangsu, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.China Pharmaceut Univ, Key Lab Biomed Funct Mat, Nanjing 210009, Peoples R China 4.Brandeis Univ, Dept Chem, Waltham, MA 02454 USA |
| 推荐引用方式 GB/T 7714 | Ling, Ya,Gao, Yuan,Shu, Chang,et al. Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect[J]. Rsc advances,2015,5(123):101475-101479. |
| APA | Ling, Ya,Gao, Yuan,Shu, Chang,Zhou, Ying,Zhong, Wenying,&Xu, Bing.(2015).Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect.Rsc advances,5(123),101475-101479. |
| MLA | Ling, Ya,et al."Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect".Rsc advances 5.123(2015):101475-101479. |
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来源：高能物理研究所
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