Mesoscale simulations and experimental studies of ph-sensitive micelles for controlled drug delivery
文献类型：期刊论文
| 作者 | Wang, Yan1,2; Li, Qiu Yu1; Liu, Xu Bo1; Zhang, Can Yang3; Wu, Zhi Min2; Guo, Xin Dong1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2015-11-25 |
| 卷号 | 7期号:46页码:25592-25600 |
| 关键词 | Dissipative particle dynamics simulation Ph-sensitive micelle Drug delivery Drug release Drug distriubtion |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.5b08366 |
| 通讯作者 | Zhang, can yang(zhangcy@nanoctr.cn) |
| 英文摘要 | The microstructures of doxorubicin-loaded micelles prepared from block polymers his(x)lys(10) (x = 0, 5, 10) conjugated with docosahexaenoic acid (dha) are investigated under different ph conditions, using dissipative particle dynamics (dpd) simulations. the conformation of micelles and the dox distributions in micelles were obviously influenced by ph values and the length of the histidine segment. at ph >6.0, the micelles self-assembled from the polymers were dense and compact. the drugs were entrapped well within the micellar core. the particle size increases as the histidine length increases. with the decrease of ph value to be lower than 6.0, there was no distinct difference for the micelles self-assembled from the polymer without histidine residues. however, the micelles prepared from the polymers with histidine residues shows a structural transformation from dense to swollen conformation, leading to an increased particle size from 10.3 to 14.5 dpd units for dhd-his(10)lys(10) micelles. this structural transformation of micelles can accelerate the dox release from micelles under lower ph conditions. the in vitro drug release from micelles is accelerated by the decrease of ph value from 7.4 (physiological environment) to 5.0 (lysosomal environment). the integration of simulation and experiments might be a valuable method for the optimization and design of biomaterials for drug delivery with desired properties |
| WOS关键词 | DISSIPATIVE PARTICLE DYNAMICS ; BLOCK-COPOLYMER MICELLES ; MESOSCOPIC SIMULATION ; MOLECULAR-DYNAMICS ; POLYMERIC MICELLES ; RELEASE MECHANISM ; ANTICANCER DRUGS ; AMPHIPHILIC COPOLYMER ; MULTIDRUG-RESISTANCE ; DIBLOCK COPOLYMERS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000366005600007 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176439 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhang, Can Yang |
| 作者单位 | 1.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China 2.Xiangtan Univ, Sch Chem Engn, Xiangtan 411105, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yan,Li, Qiu Yu,Liu, Xu Bo,et al. Mesoscale simulations and experimental studies of ph-sensitive micelles for controlled drug delivery[J]. Acs applied materials & interfaces,2015,7(46):25592-25600. |
| APA | Wang, Yan,Li, Qiu Yu,Liu, Xu Bo,Zhang, Can Yang,Wu, Zhi Min,&Guo, Xin Dong.(2015).Mesoscale simulations and experimental studies of ph-sensitive micelles for controlled drug delivery.Acs applied materials & interfaces,7(46),25592-25600. |
| MLA | Wang, Yan,et al."Mesoscale simulations and experimental studies of ph-sensitive micelles for controlled drug delivery".Acs applied materials & interfaces 7.46(2015):25592-25600. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。