Multistage vector (msv) therapeutics
文献类型：期刊论文
| 作者 | Wolfram, Joy1,2; Shen, Haifa1,3; Ferrari, Mauro1,4 |
| 刊名 | Journal of controlled release
 |
| 出版日期 | 2015-12-10 |
| 卷号 | 219页码:406-415 |
| 关键词 | Biological barriers Cancer therapy Geometrical targeting Porous silicon Transport oncophysics |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2015.08.010 |
| 通讯作者 | Ferrari, mauro(mferrari@houstonmethodist.org) |
| 英文摘要 | One of the greatest challenges in the field of medicine is obtaining controlled distribution of systemically administered therapeutic agents within the body. indeed, biological barriers such as physical compartmentalization, pressure gradients, and excretion pathways adversely affect localized delivery of drugs to pathological tissue. the diverse nature of these barriers requires the use of multifunctional drug delivery vehicles that can overcome a wide range of sequential obstacles. in this review, we explore the role of multifunctionality in nanomedicine by primarily focusing on multistage vectors (msvs). the msv is an example of a promising therapeutic platform that incorporates several components, including a microparticle, nanoparticles, and small molecules. in particular, these components are activated in a sequential manner in order to successively address transport barriers. (c) 2015 elsevier b.v. all rights reserved. |
| WOS关键词 | POROUS SILICON NANOPARTICLES ; GELATIN-SILOXANE NANOPARTICLES ; TARGETED DRUG-DELIVERY ; RED-BLOOD-CELLS ; BREAST-CANCER ; IN-VIVO ; MACROMOLECULAR THERAPEUTICS ; SOLID TUMORS ; TUMORITROPIC ACCUMULATION ; GEOMETRICAL CONFINEMENT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000365587800033 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176443 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Ferrari, Mauro |
| 作者单位 | 1.Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA 2.Univ Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY 10065 USA 4.Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA |
| 推荐引用方式 GB/T 7714 | Wolfram, Joy,Shen, Haifa,Ferrari, Mauro. Multistage vector (msv) therapeutics[J]. Journal of controlled release,2015,219:406-415. |
| APA | Wolfram, Joy,Shen, Haifa,&Ferrari, Mauro.(2015).Multistage vector (msv) therapeutics.Journal of controlled release,219,406-415. |
| MLA | Wolfram, Joy,et al."Multistage vector (msv) therapeutics".Journal of controlled release 219(2015):406-415. |
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来源：高能物理研究所
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