Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo
文献类型：期刊论文
| 作者 | An, Qiao1; Liu, Jing2; Yu, Meng1; Wan, Jiaxun1; Li, Dian1; Wang, Changchun1; Chen, Chunying2; Guo, Jia1 |
| 刊名 | Small
 |
| 出版日期 | 2015-11-11 |
| 卷号 | 11期号:42页码:5675-5686 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201501491 |
| 通讯作者 | Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | To overcome traditional barriers in optical imaging and microscopy, optoacoustic-imaging has been changed to combine the accuracy of spectroscopy with the depth resolution of ultrasound, achieving a novel modality with powerful in vivo imaging. however, magnetic resonance imaging provides better spatial and anatomical resolution. thus, a single hybrid nanoprobe that allows for simultaneous multimodal imaging is significant not only for cutting edge research in imaging science, but also for accurate clinical diagnosis. a core-shell-structured coordination polymer composite microsphere has been designed for in vivo multimodality imaging. it consists of a fe3o4 nanocluster core, a carbon sandwiched layer, and a carbocyanine-gd-iii (cy-gd-iii) coordination polymer outer shell (fe3o4@c@cy-gd-iii). folic acid-conjugated poly(ethylene glycol) chains are embedded within the coordination polymer shell to achieve extended circulation and targeted delivery of probe particles in vivo. control of fe3o4 core grain sizes results in optimal r(2) relaxivity (224.5 x 10(-3) m-1 s(-1)) for t-2-weighted magnetic resonance imaging. cy-gd-iii coordination polymers are also regulated to obtain a maximum 25.1% of cy ligands and 5.2% of gd-iii ions for near-infrared fluorescence and t-1-weighted magnetic resonance imaging, respectively. the results demonstrate their impressive abilities for targeted, multimodal, and reliable imaging. |
| WOS关键词 | MRI CONTRAST AGENTS ; COLLOIDAL PARTICLES ; FLUORESCENT DYES ; DRUG-RELEASE ; CANCER-CELLS ; DESIGN ; PROBES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000364692700009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176464 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Chunying |
| 作者单位 | 1.Fudan Univ, Dept Macromol Sci, Collaborat Innovat Ctr Polymers & Polymer Composi, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, Qiao,Liu, Jing,Yu, Meng,et al. Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo[J]. Small,2015,11(42):5675-5686. |
| APA | An, Qiao.,Liu, Jing.,Yu, Meng.,Wan, Jiaxun.,Li, Dian.,...&Guo, Jia.(2015).Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo.Small,11(42),5675-5686. |
| MLA | An, Qiao,et al."Multifunctional magnetic gd3+-based coordination polymer nanoparticles: combination of magnetic resonance and multispectral optoacoustic detections for tumor-targeted imaging in vivo".Small 11.42(2015):5675-5686. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。