Effects of buffers and ph on the reaction of a trans-platinum complex with 5-guanosine monophosphate
文献类型：期刊论文
| 作者 | Li, Chan1,2; Ding, Yi1; Cheng, Lanjun1; Zheng, Yuchuan3; Sletten, Einar4; Liu, Yangzhong1 |
| 刊名 | European journal of inorganic chemistry
 |
| 出版日期 | 2015-10-01 |
| 期号 | 29页码:4914-4920 |
| 关键词 | Platinum Antitumor agents Dna Medicinal chemistry |
| ISSN号 | 1434-1948 |
| DOI | 10.1002/ejic.201500728 |
| 通讯作者 | Zheng, yuchuan(zhengyc@hsu.edu.cn) |
| 英文摘要 | The aquation of platinum anticancer drugs is a crucial step for their activation and the consequent binding to the target dna. these processes can be influenced by small molecules, such as carbonate and phosphate, which are present in high concentration in physiological conditions. in this work, the effects of buffer and ph on the reaction of trans-ee {trans-[ptcl2{e-hn=c(och3)ch3}(2)]} with 5-guanosine monophosphate (5-gmp) have been studied in detail. the reactions were monitored by hplc at different ph in the presence of carbonate, phosphate, and hepes [4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid] buffers. trans-ee showed a very low affinity for the nitrogen atoms of hepes, but formed monofunctional adducts with carbonate and phosphate ions. the platination of gmp by trans-ee was significantly affected by the choice of buffer and ph. carbonate buffer decreased the reaction rate, mostly due to its competition with gmp. although phosphate buffer formed a similar monofunctional adduct with trans-ee, it had a negligible effect on the platination rate of gmp. this may be due to the formation of ternary adducts with trans-ee and gmp. in all cases, the platination reaction was slower at higher ph, probably due to the deprotonation of an aqua ligand on the mono-aqua complex of trans-ee. the results in this paper indicate that the solution conditions have a different effect on the reaction of trans-platinum complexes compared with cisplatin. |
| WOS关键词 | ANTITUMOR DRUG ; AQUA-LIGANDS ; DNA-ADDUCTS ; CISPLATIN ; NMR ; CIS-DIAMMINEDICHLOROPLATINUM(II) ; CHEMOTHERAPY ; METHIONINE ; SPECTROSCOPY ; EQUILIBRIUM |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| WOS记录号 | WOS:000363483900013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176484 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zheng, Yuchuan |
| 作者单位 | 1.Univ Sci & Technol China, Dept Chem, CAS High Magnet Field Lab, Hefei 230026, Anhui, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Huangshan Univ, Dept Chem, Huangshan 245041, Anhui, Peoples R China 4.Univ Bergen, Dept Chem, N-5007 Bergen, Norway |
| 推荐引用方式 GB/T 7714 | Li, Chan,Ding, Yi,Cheng, Lanjun,et al. Effects of buffers and ph on the reaction of a trans-platinum complex with 5-guanosine monophosphate[J]. European journal of inorganic chemistry,2015(29):4914-4920. |
| APA | Li, Chan,Ding, Yi,Cheng, Lanjun,Zheng, Yuchuan,Sletten, Einar,&Liu, Yangzhong.(2015).Effects of buffers and ph on the reaction of a trans-platinum complex with 5-guanosine monophosphate.European journal of inorganic chemistry(29),4914-4920. |
| MLA | Li, Chan,et al."Effects of buffers and ph on the reaction of a trans-platinum complex with 5-guanosine monophosphate".European journal of inorganic chemistry .29(2015):4914-4920. |
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