Micelle-like luminescent nanoparticles as a visible gene delivery system with reduced toxicity
文献类型：期刊论文
| 作者 | Yang, Keni1,2; Li, Shengliang1; Jin, Shubin1; Xue, Xiangdong1; Zhang, Tingbin1; Zhang, Chunqiu1; Xu, Jing1; Liang, Xing-Jie1 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:42页码:8394-8400 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c5tb01225b |
| 通讯作者 | Zhang, chunqiu(zhangcq@nanoctr.cn) |
| 英文摘要 | Cationic polymers have been widely used as promising non-viral gene carriers, but their undesirable toxicity is a drawback. hydrophobic modification has been developed as an efficient strategy to overcome this disadvantage. in this study, 25 kda polyethyleneimine (pei), the gold standard of polycations for effective gene delivery, was modified with the hydrophobic luminogen tetraphenylethene (tpe), which shows aggregation-induced emission (aie) and has been utilized as a luminescent probe in various applications. the modified pei (tpei) self-assembled into micelle-like nanoparticles (tpei-nps) and displayed aie behavior in aqueous media. the tpei-nps exhibited bright blue fluorescence and were suitable for long-term cell imaging. compared with pei, tpei-nps showed lower cytotoxicity but the transfection efficiency was nearly high. therefore, the modification of polycations with hydrophobic fluorescent molecules represents an advanced strategy for designing visible gene vehicles with low toxicity. |
| WOS关键词 | AGGREGATION-INDUCED EMISSION ; QUANTUM DOTS ; TRANSFECTION ; CARRIER ; PEI |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000363868000016 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176485 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhang, Chunqiu |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Keni,Li, Shengliang,Jin, Shubin,et al. Micelle-like luminescent nanoparticles as a visible gene delivery system with reduced toxicity[J]. Journal of materials chemistry b,2015,3(42):8394-8400. |
| APA | Yang, Keni.,Li, Shengliang.,Jin, Shubin.,Xue, Xiangdong.,Zhang, Tingbin.,...&Liang, Xing-Jie.(2015).Micelle-like luminescent nanoparticles as a visible gene delivery system with reduced toxicity.Journal of materials chemistry b,3(42),8394-8400. |
| MLA | Yang, Keni,et al."Micelle-like luminescent nanoparticles as a visible gene delivery system with reduced toxicity".Journal of materials chemistry b 3.42(2015):8394-8400. |
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来源：高能物理研究所
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