Synthesis of aqueous aglns/zns@pei as a self-indicating nonviral vector for plasmid dna self-tracking delivery
文献类型：期刊论文
| 作者 | Yang, Wentao1; Guo, Weisheng2; Zhang, Tingbin2; Yang, Weitao1; Su, Lin1; Fang, Lei1; Wang, Hanjie1; Gong, Xiaoqun1; Chang, Jin1,3,4 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:43页码:8518-8527 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c5tb01333j |
| 通讯作者 | Gong, xiaoqun(gongxiaoqun@tju.edu.cn) |
| 英文摘要 | Various nanoparticles have been employed for gene delivery. revealing the endocytosis or phagocytosis behaviors of the gene delivery system is critical for designing sophisticated gene therapies. herein, a kind of water-soluble pei capped agins/zns (zais@pei) quantum dot was synthesized as a self-indicating gene vector in the presence of branched polyethylenimine (pei) and mercaptopropionic acid (mpa). the as-prepared zais@pei qds could efficiently condense plasmid dna into nanocomplexes with strong fluorescence, which can reveal their positions during gene transfection. our results confirmed that zais@pei could mediate plasmid dna delivery into hela cells with the high transfection efficiency of 40% and low cytotoxicity, meanwhile allowing the real-time monitoring of gene transfection. the obtained zais@pei qds were verified as versatile self-tracking gene vectors, which integrated gene delivery with bioimaging functions without external labeling. |
| WOS关键词 | QUANTUM DOTS ; GENE DELIVERY ; AGINS2/ZNS NANOCRYSTALS ; CELLULAR UPTAKE ; SIRNA DELIVERY ; CANCER ; NANOPARTICLES ; RESISTANCE ; EFFICIENCY ; TOXICITY |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000364103100011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176487 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gong, Xiaoqun |
| 作者单位 | 1.Tianjin Univ, Sch Mat Sci & Engn, Sch Life Sci, Tianjin 300072, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Tianjin 300072, Peoples R China 4.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Wentao,Guo, Weisheng,Zhang, Tingbin,et al. Synthesis of aqueous aglns/zns@pei as a self-indicating nonviral vector for plasmid dna self-tracking delivery[J]. Journal of materials chemistry b,2015,3(43):8518-8527. |
| APA | Yang, Wentao.,Guo, Weisheng.,Zhang, Tingbin.,Yang, Weitao.,Su, Lin.,...&Chang, Jin.(2015).Synthesis of aqueous aglns/zns@pei as a self-indicating nonviral vector for plasmid dna self-tracking delivery.Journal of materials chemistry b,3(43),8518-8527. |
| MLA | Yang, Wentao,et al."Synthesis of aqueous aglns/zns@pei as a self-indicating nonviral vector for plasmid dna self-tracking delivery".Journal of materials chemistry b 3.43(2015):8518-8527. |
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来源：高能物理研究所
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