Her2 targeting peptides screening and applications in tumor imaging and drug delivery
文献类型：期刊论文
| 作者 | Geng, Lingling1,3; Wang, Zihua1,2; Jia, Xiangqian1,4; Han, Qiuju1,4; Xiang, Zhichu1,2; Li, Dan1,2; Yang, Xiaoliang1,2; Zhang, Di1; Bu, Xiangli1,2; Wang, Weizhi1,2 |
| 刊名 | Theranostics
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:8页码:1261-1273 |
| 关键词 | Her2 targeting peptide Tumor imaging Drug delivery Breast cancer Md simulation |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.14302 |
| 通讯作者 | Wang, weizhi(wangwz@nanoctr.cn) ; Hu, zhiyuan(huzy@nanoctr.cn) ; Fang, qiaojun(fangqj@nanoctr.cn) |
| 英文摘要 | Herein, computational-aided one-bead-one-compound (oboc) peptide library design combined with in situ single-bead sequencing microarray methods were successfully applied in screening peptides targeting at human epidermal growth factor receptor-2 (her2), a biomarker of human breast cancer. as a result, 72 novel peptides clustered into three sequence motifs which are pyl*** np, yyl*** np and ppl*** np were acquired. particularly one of the peptides, p51, has nanomolar affinity and high specificity for her2 in ex vivo and in vivo tests. moreover, doxorubicin (dox)-loaded liposome nanoparticles were modified with peptide p51 or p25 and demonstrated to improve the targeted delivery against her2 positive cells. our study provides an efficient peptide screening method with a combination of techniques and the novel screened peptides with a clear binding site on her2 can be used as probes for tumor imaging and targeted drug delivery. |
| WOS关键词 | SURFACE-PLASMON RESONANCE ; FREE-ENERGY CALCULATIONS ; EPIDERMAL-GROWTH-FACTOR ; ERBB SIGNALING NETWORK ; MOLECULAR-MECHANICS ; BREAST-CANCER ; CONTINUUM MODELS ; HIGH-AFFINITY ; CELL-LINES ; LIPOSOMES |
| WOS研究方向 | Research & Experimental Medicine |
| WOS类目 | Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000378529400015 |
| 出版者 | IVYSPRING INT PUBL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176499 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Weizhi; Hu, Zhiyuan; Fang, Qiaojun |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 4.Liaoning Med Univ, Coll Pharm, Jinzhou 121001, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Lingling,Wang, Zihua,Jia, Xiangqian,et al. Her2 targeting peptides screening and applications in tumor imaging and drug delivery[J]. Theranostics,2016,6(8):1261-1273. |
| APA | Geng, Lingling.,Wang, Zihua.,Jia, Xiangqian.,Han, Qiuju.,Xiang, Zhichu.,...&Fang, Qiaojun.(2016).Her2 targeting peptides screening and applications in tumor imaging and drug delivery.Theranostics,6(8),1261-1273. |
| MLA | Geng, Lingling,et al."Her2 targeting peptides screening and applications in tumor imaging and drug delivery".Theranostics 6.8(2016):1261-1273. |
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来源：高能物理研究所
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