Iron homeostasis: transport, metabolism, and regulation
文献类型：期刊论文
| 作者 | Guo, Shanshan1,2; Frazer, David M.1; Anderson, Gregory J.1 |
| 刊名 | Current opinion in clinical nutrition and metabolic care
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 19期号:4页码:276-281 |
| ISSN号 | 1363-1950 |
| 关键词 | Anaemia Ferroportin Hepcidin Iron homeostasis Iron transport |
| DOI | 10.1097/mco.0000000000000285 |
| 通讯作者 | Anderson, gregory j.(greg.anderson@qimrberghofer.edu.au) |
| 英文摘要 | Purpose of reviewiron is essential for normal cellular function and many diseases result from disturbances in iron homeostasis. this review describes some of the recent key advances in iron transport and its regulation, how this relates to iron-related disorders, and emerging therapies for these diseases.recent findingsthe iron-regulatory hormone hepcidin and its target, the iron exporter ferroportin (fpn), play central roles in iron homeostasis. recent studies have expanded our understanding of how hepcidin is regulated in response to stimulated erythropoiesis and have added some new players to the complex network of factors that influences hepcidin expression. novel structural insights into how fpn transports iron have been an important addition to the field, as has the recognition that some zinc transporters such as zip14 can transport iron. investigations into cardiac iron homeostasis have revealed a key role for fpn, and transferrin receptor 1, which is essential for cellular iron uptake, has been shown to be critical for normal immune function.summarythe increased understanding of mechanisms of iron homeostasis that has resulted from recent research has greatly improved our ability to diagnose and manage iron-related disorders, and has offered new therapies for this important class of human diseases. |
| WOS关键词 | HEPCIDIN ; OVERLOAD ; HEMOCHROMATOSIS ; ERYTHROFERRONE ; TRAFFICKING ; MECHANISMS ; MOLECULES ; PATHWAY ; HUMANS ; ZIP14 |
| WOS研究方向 | Endocrinology & Metabolism ; Nutrition & Dietetics |
| WOS类目 | Endocrinology & Metabolism ; Nutrition & Dietetics |
| 语种 | 英语 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| WOS记录号 | WOS:000378418700006 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176501 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Anderson, Gregory J. |
| 作者单位 | 1.QIMR Berghofer Med Res Inst, Iron Metab Lab, Brisbane, Qld, Australia 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Shanshan,Frazer, David M.,Anderson, Gregory J.. Iron homeostasis: transport, metabolism, and regulation[J]. Current opinion in clinical nutrition and metabolic care,2016,19(4):276-281. |
| APA | Guo, Shanshan,Frazer, David M.,&Anderson, Gregory J..(2016).Iron homeostasis: transport, metabolism, and regulation.Current opinion in clinical nutrition and metabolic care,19(4),276-281. |
| MLA | Guo, Shanshan,et al."Iron homeostasis: transport, metabolism, and regulation".Current opinion in clinical nutrition and metabolic care 19.4(2016):276-281. |
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来源：高能物理研究所
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