Preparation and biological evaluation of tc-99m-labeled pteroyl-lys derivatives
文献类型：期刊论文
| 作者 | Yu Qian1; He Yingfang1; Chen Yuan1; Yang Wenjiang2; Zhang Chun3; Lu Jie1 |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2015-12-10 |
| 卷号 | 36期号:12页码:2446-2453 |
| 关键词 | Tc-99m Folate receptor Pteroyl-lys derivative Tumor imaging |
| ISSN号 | 0251-0790 |
| DOI | 10.7503/cjcu20150388 |
| 通讯作者 | Lu jie(ljie74@bnu.edu.cn) |
| 英文摘要 | Two tc-99m labeled complexes, tc-99m (hynic-penta-lys-pteroyl) (tricine/tppts) and tc-99m-(hynic-gly-gly-lys-pteroyl)(tricine/tppts), were prepared based on the structure of pteroyl-lys. both two complexes exhibited high receptor specific binding and extended retention in kb human epidermoid carcinoma cells. the tumor uptake values of tc-99m(hynic-penta-lys-pteroyl) (tricine/tppts) and tc-99m(hynic-gly-gly-lys-pteroyl)(tricine/tppts) were (8. 55 +/- 2. 78)% id/g and (9. 77 +/- 1. 54)% id/g at 1 h postinjection, respectively. flank kb tumors were clearly visualized with tc-99m(hynic-penta-lys-pteroyl) (tricine/tppts) and tc-99m(hynic-gly-gly-lys-pteroyl) (tricine/tppts) by micro-spect/ct images at 2 h postinjection. high receptor-specific tumor uptakes coupled with fast non-target tissues clearance demonstrated the feasibility of using tc-99m-labeled pteroyl-lys derivatives as novel imaging probes for fr-positive tumors detection. |
| WOS关键词 | FOLATE RECEPTOR ISOFORMS ; OVARIAN-CANCER ; CELL-LINES ; ACID ; THERAPY ; TISSUES ; AGENT |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000369592900014 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176513 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Lu Jie |
| 作者单位 | 1.Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Radiat & Nucl Energy Technol, Beijing 100142, Peoples R China 3.Capital Med Univ, Beijing Chao Yang Hosp, Dept Nucl Med, Beijing 100020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu Qian,He Yingfang,Chen Yuan,et al. Preparation and biological evaluation of tc-99m-labeled pteroyl-lys derivatives[J]. Chemical journal of chinese universities-chinese,2015,36(12):2446-2453. |
| APA | Yu Qian,He Yingfang,Chen Yuan,Yang Wenjiang,Zhang Chun,&Lu Jie.(2015).Preparation and biological evaluation of tc-99m-labeled pteroyl-lys derivatives.Chemical journal of chinese universities-chinese,36(12),2446-2453. |
| MLA | Yu Qian,et al."Preparation and biological evaluation of tc-99m-labeled pteroyl-lys derivatives".Chemical journal of chinese universities-chinese 36.12(2015):2446-2453. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。