A photosensitizer-loaded dna origami nanosystem for photodynamic therapy
文献类型：期刊论文
| 作者 | Zhuang, Xiaoxi1; Ma, Xiaowei1; Xue, Xiangdong1; Jiang, Qiao2; Song, Linlin2; Dai, Luru2; Zhang, Chunqiu1; Jin, Shubin1; Yang, Keni1; Ding, Baoquan2 |
| 刊名 | Acs nano
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 10期号:3页码:3486-3495 |
| 关键词 | Carbazole derivative photosensitizer Dna origami Intracellular imaging Photodynamic therapy Dual-functionality |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.5b07671 |
| 通讯作者 | Ma, xiaowei(maxw@nanoctr.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Photodynamic therapy (pdt) offers an alternative for cancer treatment by using ultraviolet or visible light in the presence of a photosensitizer and molecular oxygen, which can produce highly reactive oxygen species that ultimately leading to the ablation of tumor cells by multifactorial mechanisms. however, this technique is limited by the penetration depth of incident light, the hypoxic environment of solid tumors, and the vulnerability of photobleaching reduces the efficiency of many imaging agents. in this work, we reported a cellular level dual-functional imaging and pdt nanosystem bmepc-loaded dna origami for photodynamic therapy with high efficiency and stable photoreactive property. the carbazole derivative bmepc is a one- and two-photon imaging agent and photosensitizer with large two-photon absorption cross section, which can be fully excited by near-infrared light, and is also capable of destroying targets under anaerobic condition by generating reactive intermediates of type i photodynamic reactions. however, the application of bmepc was restricted by its poor solubility in aqueous environment and its aggregation caused quenching. we observed bmepc-loaded dna origami effectively reduced the photobleaching of bmepc within cells. upon binding to dna origami, the intramolecular rotation of bmepc became proper restricted, which intensify fluorescence emission and radicals production when being excited. after the bmepc-loaded dna origami are taken up by tumor cells, upon irradiation, bmepc could generate free radicals and be released due to dna photocleavage as well as the following partially degradation. apoptosis was then induced by the generation of free radicals. this functional nanosystem provides an insight into the design of photosensitizer-loaded dna origami for effective intracellular imaging and photodynamic therapy. |
| WOS关键词 | HIGH-GRADE DYSPLASIA ; BARRETTS-ESOPHAGUS ; TALAPORFIN SODIUM ; CELL-DEATH ; CANCER ; MECHANISMS ; PDT ; LOCALIZATION ; ABLATION ; DELIVERY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000372855400051 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176516 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Ma, Xiaowei; Liang, Xing-Jie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R China 3.Fu Jen Catholic Univ, Taipei 24205, Taiwan 4.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA |
| 推荐引用方式 GB/T 7714 | Zhuang, Xiaoxi,Ma, Xiaowei,Xue, Xiangdong,et al. A photosensitizer-loaded dna origami nanosystem for photodynamic therapy[J]. Acs nano,2016,10(3):3486-3495. |
| APA | Zhuang, Xiaoxi.,Ma, Xiaowei.,Xue, Xiangdong.,Jiang, Qiao.,Song, Linlin.,...&Liang, Xing-Jie.(2016).A photosensitizer-loaded dna origami nanosystem for photodynamic therapy.Acs nano,10(3),3486-3495. |
| MLA | Zhuang, Xiaoxi,et al."A photosensitizer-loaded dna origami nanosystem for photodynamic therapy".Acs nano 10.3(2016):3486-3495. |
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来源：高能物理研究所
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