Cerebral glucose metabolism assessment in rat models of alzheimer's disease: an f-18-fdg-pet study
文献类型：期刊论文
| 作者 | Lu, Yangjia1,2; Ren, Jie1; Cui, Shaoyang3,4; Chen, Junqi1,5; Huang, Yong1; Tang, Chunzhi2; Shan, Baoci6; Nie, Bingbing6; Lai Xinsheng3 |
| 刊名 | American journal of alzheimers disease and other dementias
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 31期号:4页码:333-340 |
| ISSN号 | 1533-3175 |
| 关键词 | Alzheimer's disease Rat model Pet Metabolism |
| DOI | 10.1177/1533317515617725 |
| 通讯作者 | Huang, yong(nanfanglihuang@163.com) ; Tang, chunzhi(jordan64@163.com) |
| 英文摘要 | Objective: this study was designed to detect the brain glucose metabolism in rat models of alzheimer's disease (ad) by the application of f-18-2-fluoro-deoxy-d-glucose positron emission tomography (f-18-fdg-pet) and to provide new insights for the early detection of ad. methods: forty wistar rats were randomly divided into 2 groups. fifteen sham-operated rats were used as a control group. the remaining rats as a premodel group were intracerebroventricularly injected with ibotenic acid and were intraperitoneally injected with d-galactose, of which 15 rats were included as the experimental group. the above-mentioned 2 groups were assigned to y-maze test and underwent f-18-fdg-pet scanning. positron emission tomography images were processed with spm 2.0. results: the learning and memory skills were weakened in ad rats. besides, the glucose metabolic activity of ad rats decreased in hippolampus, hypothalamus, insular cortex, piriform cortex, striatum, cingulate gyrus, stria terminalis, and parietal lobe and increased in olfactory bulb, cerebellum, midbrain, pontine, and retrosplenial cortex compared with the control group. dorsal thalamus had shown both enhanced and reduced glucose metabolic activity. conclusion: our data indicate that the changed glucose metabolism in cerebral regions in f-18-fdg-pet imaging could be an important predictor for early ad. |
| WOS关键词 | MILD COGNITIVE IMPAIRMENT ; FDG-PET ; MOUSE MODEL ; ASSOCIATION WORKGROUPS ; DIAGNOSTIC GUIDELINES ; OLFACTORY DYSFUNCTION ; NATIONAL INSTITUTE ; PARIETAL LOBE ; BLOOD-FLOW ; DEMENTIA |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| WOS类目 | Geriatrics & Gerontology ; Clinical Neurology |
| 语种 | 英语 |
| 出版者 | SAGE PUBLICATIONS INC |
| WOS记录号 | WOS:000376305200005 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176537 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Huang, Yong; Tang, Chunzhi |
| 作者单位 | 1.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China 2.Guangdong Med Coll, Dept Tradit Chinese Med, Dongguan, Peoples R China 3.Guangzhou Univ Tradit Chinese Med, Dept Acupuncture & Massage, Guangzhou, Guangdong, Peoples R China 4.Futian TCM Hosp, Dept Acupuncture & Moxibust, Shenzhen, Peoples R China 5.Southern Med Univ, Affiliated Hosp 3, Dept Rehabil, Guangzhou, Guangdong, Peoples R China 6.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Yangjia,Ren, Jie,Cui, Shaoyang,et al. Cerebral glucose metabolism assessment in rat models of alzheimer's disease: an f-18-fdg-pet study[J]. American journal of alzheimers disease and other dementias,2016,31(4):333-340. |
| APA | Lu, Yangjia.,Ren, Jie.,Cui, Shaoyang.,Chen, Junqi.,Huang, Yong.,...&Lai Xinsheng.(2016).Cerebral glucose metabolism assessment in rat models of alzheimer's disease: an f-18-fdg-pet study.American journal of alzheimers disease and other dementias,31(4),333-340. |
| MLA | Lu, Yangjia,et al."Cerebral glucose metabolism assessment in rat models of alzheimer's disease: an f-18-fdg-pet study".American journal of alzheimers disease and other dementias 31.4(2016):333-340. |
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来源：高能物理研究所
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