Nanoscale polymersomes as anti-cancer drug carriers applied for pharmaceutical delivery
文献类型：期刊论文
| 作者 | Tuguntaev, Ruslan G.1; Okeke, Chukwunweike Ikechukwu1; Xu, Jing1; Li, Chan1; Wang, Paul C.2,3; Liang, Xing-Jie1 |
| 刊名 | Current pharmaceutical design
 |
| 出版日期 | 2016 |
| 卷号 | 22期号:19页码:2857-2865 |
| 关键词 | Polymersomes Amphiphilic block copolymers Pharmaceutical delivery Hydrophobic drugs Hydrophilic drugs Co-loading Preparation methods |
| ISSN号 | 1381-6128 |
| DOI | 10.2174/1381612822666160217142319 |
| 通讯作者 | Li, chan(lic@nanoctr.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Polymersomes are self-assembled nano-vesicles composed of amphiphilic block copolymers. these building blocks can be selected from a large number of hydrophilic and hydrophobic polymers in order to achieve required properties of the final system, such as biodegradability, sustainable and multiple stimuli-response drug release, long blood circulation, and low toxicity. moreover, the surface of polymersomes can be functionalized to induce targeting character. polymersomes are able to encapsulate a broad range of hydrophilic or/and hydrophobic molecules either in the aqueous core or membrane bilayer, respectively. in addition, colloidal stability and low membrane fluidity make polymersomes attractive nano-sized drug carriers. the review describes polymersomes compositions, their applications in pharmaceutical delivery, and preparation methods. |
| WOS关键词 | DEGRADABLE CHIMERIC POLYMERSOMES ; AMPHIPHILIC BLOCK-COPOLYMERS ; BIODEGRADABLE POLYMERSOMES ; CANCER-CELLS ; DOXORUBICIN HYDROCHLORIDE ; INTRACELLULAR DELIVERY ; PLGA NANOPOLYMERSOMES ; DIBLOCK COPOLYMERS ; TRIBLOCK COPOLYMER ; TRIGGERED RELEASE |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000376452700008 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176538 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Chan; Liang, Xing-Jie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 2.Fu Jen Catholic Univ, Taipei 24205, Taiwan 3.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA |
| 推荐引用方式 GB/T 7714 | Tuguntaev, Ruslan G.,Okeke, Chukwunweike Ikechukwu,Xu, Jing,et al. Nanoscale polymersomes as anti-cancer drug carriers applied for pharmaceutical delivery[J]. Current pharmaceutical design,2016,22(19):2857-2865. |
| APA | Tuguntaev, Ruslan G.,Okeke, Chukwunweike Ikechukwu,Xu, Jing,Li, Chan,Wang, Paul C.,&Liang, Xing-Jie.(2016).Nanoscale polymersomes as anti-cancer drug carriers applied for pharmaceutical delivery.Current pharmaceutical design,22(19),2857-2865. |
| MLA | Tuguntaev, Ruslan G.,et al."Nanoscale polymersomes as anti-cancer drug carriers applied for pharmaceutical delivery".Current pharmaceutical design 22.19(2016):2857-2865. |
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来源：高能物理研究所
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