Simultaneous determination of 22 cephalosporins drug residues in pork muscle using liquid chromatography-tandem mass spectrometry
文献类型：期刊论文
| 作者 | Li, Weiqing1; Shen, Haiying2,3; Hong, Yunhe1,4; Zhang, Yuan1,5; Yuan, Fei1; Zhang, Feng1 |
| 刊名 | Journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 1022页码:298-307 |
| 关键词 | Liquid chromatography Tandem mass spectrometry Cephalosporins Muscle |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2016.04.026 |
| 通讯作者 | Zhang, feng(fengzhang@126.com) |
| 英文摘要 | A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 22 common cephalosporins from the first generation to the fourth generation in pork muscle by liquid chromatographic-tandem mass spectrometric (lc-ms/ms) method. under the optimized extraction conditions, samples were directly purified through membrane filtration to separate all 22 cephalosporins and the critical pairs of each parent drug were completely separated. variables affecting the lc-ms/ms were optimized to get a better separation. the excellent selectivity and sensitivity achieved in multiple reactions monitoring (mrm) mode allowed satisfactory confirmation and quantitation for the 22 cephalosporins. the linear range of the 22 cephalosporins is 0.06-100.0 mu g/l with good correlation coefficients (r(2) > 0.9920). the limits of detection (lods) and limits of quantitation (loqs) of these compounds were in the range 0.04-3.0 mu g/l and 0.06-10.0 mu g/kg, respectively. the average intra-day recoveries at 3 spiked levels (loq, 2loq 4loq) were all in the range 83.6-113.0% with rsds (n = 6) lower than 6.5%. the method of lc-ms/ms developed in this study was initially applied to the research of 22 cephalosporins in 12 retail pork samples and proved to be accurate, sensitive, minimum sample pre-treatment, convenient and practical. (c) 2016 elsevier b.v. all rights reserved. |
| WOS关键词 | SOLID-PHASE EXTRACTION ; RESISTANT ACINETOBACTER-BAUMANNII ; LC-MS/MS ; CAPILLARY-ELECTROPHORESIS ; CONFIRMATORY ASSAY ; MILK ; PENICILLINS ; VALIDATION ; PRETREATMENT ; ANTIBIOTICS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000376545800039 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176539 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhang, Feng |
| 作者单位 | 1.Chinese Acad Inspect & Quarantine, Inst Food Safety, Beijing 100123, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 4.Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China 5.China Med Univ, Sch Pharm, Shenyang 110013, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Weiqing,Shen, Haiying,Hong, Yunhe,et al. Simultaneous determination of 22 cephalosporins drug residues in pork muscle using liquid chromatography-tandem mass spectrometry[J]. Journal of chromatography b-analytical technologies in the biomedical and life sciences,2016,1022:298-307. |
| APA | Li, Weiqing,Shen, Haiying,Hong, Yunhe,Zhang, Yuan,Yuan, Fei,&Zhang, Feng.(2016).Simultaneous determination of 22 cephalosporins drug residues in pork muscle using liquid chromatography-tandem mass spectrometry.Journal of chromatography b-analytical technologies in the biomedical and life sciences,1022,298-307. |
| MLA | Li, Weiqing,et al."Simultaneous determination of 22 cephalosporins drug residues in pork muscle using liquid chromatography-tandem mass spectrometry".Journal of chromatography b-analytical technologies in the biomedical and life sciences 1022(2016):298-307. |
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