Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-b activation
文献类型：期刊论文
| 作者 | Pan, Yuanming1; Lin, Shuye2,3; Xing, Rui1; Zhu, Min1; Lin, Bonan2; Cui, Jiantao1; Li, Wenmei1; Gao, Jing4; Shen, Lin4; Zhao, Yuanyuan5 |
| 刊名 | Antioxidants & redox signaling
 |
| 出版日期 | 2016-05-20 |
| 卷号 | 24期号:15页码:839-854 |
| ISSN号 | 1523-0864 |
| DOI | 10.1089/ars.2014.6128 |
| 通讯作者 | Huang, jiaqiang(jqhuang@bjtu.edu.cn) ; Lu, youyong(youyonglu@hsc.pku.edu.cn) |
| 英文摘要 | Aims: metallothionein 2a (mt2a) and nuclear factor-kappab (nf-b) are both involved in carcinogenesis and cancer chemosensitivity. we previously showed decreased expression of mt2a and ib- in human gastric cancer (gc) associated with poor prognosis of gc patients. the present study investigated the effect of diallyl trisulfide (dats), a garlic-derived compound, and docetaxel (doc) on regulation of mt2a in relation to nf-b in gc cells. results: dats attenuated nf-b signaling in gc cells, resulting in g2/m cell cycle arrest and apoptosis, culminating in the inhibition of cell proliferation and tumorigenesis in nude mice. the anti-gc effect of dats was attributable to its capacity to epigenetically upregulate mt2a, which in turn enhanced transcription of ib- to suppress nf-b activation in gc cells. the combination of dats with doc exhibited a synergistic anti-gc activity accompanied by mt2a upregulation and nf-b inactivation. histopathologic analysis of gc specimens from patients showed a significant increase in mt2a expression following doc treatment. gc patients with high mt2a expression in tumor specimens showed significantly improved response to chemotherapy and prolonged survival compared with those with low mt2a expression in tumors. innovation and conclusion: we conclude that dats exerts its anti-gc activity and enhances chemosensitivity of gc to doc by epigenetic upregulation of mt2a to attenuate nf-b signaling. our findings delineate a mechanistic basis of mt2a/nf-b signaling for dats- and doc-mediated anti-gc effects, suggesting that mt2a may be a chemosensitivity indicator in gc patients receiving doc-based treatment and a promising target for more effective treatment of gc by combination of dats and doc. antioxid. redox signal. 24, 839-854. |
| WOS关键词 | FACTOR-KAPPA-B ; HUMAN HEPATOCELLULAR CARCINOMAS ; REFRACTORY PROSTATE-CANCER ; HELICOBACTER-PYLORI ; HISTONE DEACETYLASE ; INDUCED APOPTOSIS ; OXIDATIVE STRESS ; GENE-EXPRESSION ; DOWN-REGULATION ; BREAST-CANCER |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | MARY ANN LIEBERT, INC |
| WOS记录号 | WOS:000376775200001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176540 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Huang, Jiaqiang; Lu, Youyong |
| 作者单位 | 1.Peking Univ, Mol Oncol Lab, Minist Educ, Key Lab Carcinogenesis & Translat Res,Canc Hosp I, 52 Fucheng Rd, Beijing 100142, Peoples R China 2.Beijing Jiaotong Univ, Sch Sci, Coll Life Sci & Bioengn, 3 Shangyuancun, Beijing 100044, Peoples R China 3.NCI, Mol Immunoregulat Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21701 USA 4.Peking Univ, Minist Educ, Key Lab Carcinogenesis & Translat Res, Dept GI Oncol,Sch Oncol,Peking Canc Hosp, Beijing 100871, Peoples R China 5.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Yuanming,Lin, Shuye,Xing, Rui,et al. Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-b activation[J]. Antioxidants & redox signaling,2016,24(15):839-854. |
| APA | Pan, Yuanming.,Lin, Shuye.,Xing, Rui.,Zhu, Min.,Lin, Bonan.,...&Lu, Youyong.(2016).Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-b activation.Antioxidants & redox signaling,24(15),839-854. |
| MLA | Pan, Yuanming,et al."Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-b activation".Antioxidants & redox signaling 24.15(2016):839-854. |
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