A versatile imaging and therapeutic platform based on dual-band luminescent lanthanide nanoparticles toward tumor metastasis inhibition
文献类型：期刊论文
| 作者 | Li, Yang1; Tang, Jinglong2,3; Pan, Dong-Xu1; Sun, Ling-Dong1; Chen, Chunying2,3; Liu, Ying2,3; Wang, Ye-Fu1; Shi, Shuo1; Yan, Chun-Hua1 |
| 刊名 | Acs nano
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 10期号:2页码:2766-2773 |
| 关键词 | Nd3+-sensitized lanthanide nanoparticles Upconversion emissions Nir imaging photodynamic therapy Tumor metastasis |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.5b07873 |
| 通讯作者 | Sun, ling-dong(sun@pku.edu.cn) ; Chen, chunying(chenchy@nanoctr.cn) ; Yan, chun-hua(yan@pku.edu.cn) |
| 英文摘要 | Upconversion (uc) luminescent lanthanide nanoparticles (lnps) are expected to play an important role in imaging and photodynamic therapy (pdt) in vitro and in vivo. however, with the absorption of uc emissions by photosensitizers (pss) to generate singlet oxygen (o-1(2)) for pdt, the imaging signals from lnps are significantly weakened. it is important to activate another imaging route to track the location of the lnps during pdt process. in this work, nd3+-sensitized lnps with dual -band visible and near -infrared (nir) emissions under single 808 nm excitation were reported to address this issue. the uc emissions in green could trigger covalently linked rose bengal (rb) molecules for efficient pdt, and mr emissions deriving from yb3+ and magnetic resonance imaging (mri) were used for imaging simultaneously. notably, the designed therapeutic platform could further effectively avoid the overheating effect induced by the laser irradiation, due to the minimized absorption of biological media at around 808 nm. tdt-mediated dutp nick end labeling (tunel) assay showed serious cell apoptosis in the tumor after pdt for 2 weeks, leading to an effective tumor inhibition rate of 67%. benefit from the pdt, the tumor growth -induced liver and spleen burdens were largely attenuated, and the liver injury was also alleviated. more importantly, pulmonary and hepatic tumor metastases were significantly reduced after pdt. the nd3+-sensitized lnps provide a multifunctional nanoplatform for mr light-assisted pdt with minimized heating effect and an effective inhibition of tumor growth and metastasis. |
| WOS关键词 | UP-CONVERSION NANOPARTICLES ; PHOTODYNAMIC THERAPY ; ANTITUMOR IMMUNITY ; IN-VITRO ; CANCER ; NM ; PHOTOSENSITIZERS ; PHOTOSTABILITY ; NANOMATERIALS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000370987400121 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176543 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Sun, Ling-Dong; Chen, Chunying; Yan, Chun-Hua |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Che, State Key Lab Rare Earth Mat Chem & Applicat,Beij, Beijing 100871, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yang,Tang, Jinglong,Pan, Dong-Xu,et al. A versatile imaging and therapeutic platform based on dual-band luminescent lanthanide nanoparticles toward tumor metastasis inhibition[J]. Acs nano,2016,10(2):2766-2773. |
| APA | Li, Yang.,Tang, Jinglong.,Pan, Dong-Xu.,Sun, Ling-Dong.,Chen, Chunying.,...&Yan, Chun-Hua.(2016).A versatile imaging and therapeutic platform based on dual-band luminescent lanthanide nanoparticles toward tumor metastasis inhibition.Acs nano,10(2),2766-2773. |
| MLA | Li, Yang,et al."A versatile imaging and therapeutic platform based on dual-band luminescent lanthanide nanoparticles toward tumor metastasis inhibition".Acs nano 10.2(2016):2766-2773. |
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来源：高能物理研究所
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