Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration
文献类型：期刊论文
| 作者 | Chen, Rui1,2,3; Zhao, Lin2,3; Bai, Ru2,3; Liu, Ying2,3; Han, Liping2,3; Xu, Zhifang2,3; Chen, Feng1; Autrup, Herman4; Long, Dingxin1; Chen, Chunying2,3 |
| 刊名 | Toxicology research
 |
| 出版日期 | 2016 |
| 卷号 | 5期号:2页码:602-608 |
| ISSN号 | 2045-452X |
| DOI | 10.1039/c5tx00464k |
| 通讯作者 | Long, dingxin(dxlong99@163.com) ; Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | Concerns have arisen about the health and environmental impacts of the increasing commercial use of silver nanoparticles (agnps). however, the toxic mechanisms and target tissues of agnps have not been fully defined. in this paper, we investigated the tissue toxicity of mice after intravenous administration of agnps at a single-dose of 0.2, 2 or 5 mg per kg (body weight), respectively. biodistribution, endoplasmic reticulum stress, and oxidative stress were examined in mouse organs at eight hours after exposure. stress markers, e.g. hsp70, bip, p-ire1, p-perk, chop and xbp-1s proteins/genes, were significantly upregulated in a dose-dependent manner. in the liver, spleen, lung and kidney, high stress accompanied by apoptosis occurred. low stress levels were observed in the heart and brain. thus, it is proposed that the liver, spleen, lung and kidney are dominant target tissues of agnp exposure. the lower stress and toxicity in the heart and brain were in agreement with lower agnp accumulation. the present results demonstrated that agnp exposure eventually resulted in permanent toxic damage by gradually imposing stress impacts on target organs. these findings highlight the potent applications of stress markers in future risk evaluation of silver nanoparticle toxicity. |
| WOS关键词 | REPEATED-DOSE TOXICITY ; DNA-DAMAGE ; MICE ; CELL ; APOPTOSIS ; CYTOTOXICITY ; EXPOSURE ; RATS ; PHARMACOKINETICS ; BIODISTRIBUTION |
| WOS研究方向 | Toxicology |
| WOS类目 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000371613300024 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176550 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Long, Dingxin; Chen, Chunying |
| 作者单位 | 1.Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 4.Aarhus Univ, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus C, Denmark |
| 推荐引用方式 GB/T 7714 | Chen, Rui,Zhao, Lin,Bai, Ru,et al. Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration[J]. Toxicology research,2016,5(2):602-608. |
| APA | Chen, Rui.,Zhao, Lin.,Bai, Ru.,Liu, Ying.,Han, Liping.,...&Chen, Chunying.(2016).Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration.Toxicology research,5(2),602-608. |
| MLA | Chen, Rui,et al."Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration".Toxicology research 5.2(2016):602-608. |
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