Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity
文献类型：期刊论文
| 作者 | Xu, Ligeng1; Xiang, Jian1; Liu, Ye2; Xu, Jun1; Luo, Yinchan1; Feng, Liangzhu1; Liu, Zhuang1; Peng, Rui1 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2016-02-14 |
| 卷号 | 8期号:6页码:3785-3795 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c5nr09208f |
| 通讯作者 | Peng, rui(rpeng@suda.edu.cn) |
| 英文摘要 | Benefiting from their unique physicochemical properties, graphene derivatives have attracted great attention in biomedicine. in this study, we carefully engineered graphene oxide (go) as a vaccine adjuvant for immunotherapy using urease b (ure b) as the model antigen. ure b is a specific antigen for helicobacter pylori, which is a class i carcinogen for gastric cancer. polyethylene glycol (peg) and various types of polyethylenimine (pei) were used as coating polymers. compared with single-polymer modified gos (go-peg and go-pei), certain dual-polymer modified gos (go-peg-pei) can act as a positive modulator to promote the maturation of dendritic cells (dcs) and enhance their cytokine secretion through the activation of multiple toll-like receptor (tlr) pathways while showing low toxicity. moreover, this go-peg-pei can serve as an antigen carrier to effectively shuttle antigens into dcs. these two advantages enable go-peg-pei to serve as a novel vaccine adjuvant. in the subsequent in vivo experiments, compared with free ure b and clinically used aluminum-adjuvant-based vaccine (alum-ure b), go-peg-pei-ure b induces stronger cellular immunity via intradermal administration, suggesting promising applications in cancer immunotherapy. our work not only presents a novel, highly effective go-based vaccine nano-adjuvant, but also highlights the critical roles of surface chemistry for the rational design of nano-adjuvants. |
| WOS关键词 | HELICOBACTER-PYLORI ; SIGNALING PATHWAYS ; IN-VIVO ; PHOTOTHERMAL THERAPY ; PRISTINE GRAPHENE ; TARGETED DELIVERY ; DENDRITIC CELLS ; RESPONSES ; NANOPARTICLES ; TOXICITY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000369908900071 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176557 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Peng, Rui |
| 作者单位 | 1.Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ligeng,Xiang, Jian,Liu, Ye,et al. Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity[J]. Nanoscale,2016,8(6):3785-3795. |
| APA | Xu, Ligeng.,Xiang, Jian.,Liu, Ye.,Xu, Jun.,Luo, Yinchan.,...&Peng, Rui.(2016).Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity.Nanoscale,8(6),3785-3795. |
| MLA | Xu, Ligeng,et al."Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity".Nanoscale 8.6(2016):3785-3795. |
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来源：高能物理研究所
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