Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triple-negative breast cancer
文献类型：期刊论文
| 作者 | Su, Shishuai; Ding, Yanping; Li, Yiye; Wu, Yan; Nie, Guangjun |
| 刊名 | Biomaterials
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 80页码:169-178 |
| 关键词 | Porphyrin Self-assembly Photothermal therapy Chemosensitivity Triple-negative breast cancer |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2015.11.058 |
| 通讯作者 | Wu, yan(wuy@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | Triple-negative breast cancer is a malignant cancer type with a high risk of early recurrence and distant metastasis. unlike other breast cancers, triple-negative breast cancer is lack of targetable receptors and, therefore, patients largely receive systemic chemotherapy. however, inevitable adverse effects and acquired drug resistance severely constrain the therapeutic outcome. here we tailor-designed a porphyrin-based micelle that was self-assembled from a hybrid amphiphilic polymer comprising polyethylene glycol, poly (d, l-lactide-co-glycolide) and porphyrin. the bilayer micelles can be simultaneously loaded with two chemotherapeutic drugs with synergistic cytotoxicity and distinct physiochemical properties, forming a uniform and spherical nanostructure. the drug-loaded micelles showed a tendency to accumulate in the tumor and can be internalized by tumor cells for drug release in acidic organelles. under near-infrared laser irradiation, high density of self-quenched porphyrins in the hydrophobic layer absorbed light efficiently and converted into an excited state, leading to the release of sufficient heat for photothermal therapy. the integration of localized photothermal effect and synergistic chemotherapy conferred great chemosensitivity to cancer cells and achieved tumor regression using about 1/10 of traditional drug dosage. as a result, chemotherapy-associated adverse effects were successfully avoided. our present study established a novel porphyrin-based nanoplatform with photothermal activity and expanded drug loading capacity, providing new opportunities for challenging conventional chemotherapy and fighting against stubborn triple-negative breast cancer. (c) 2015 elsevier ltd. all rights reserved. |
| WOS关键词 | ENHANCED ANTITUMOR EFFICACY ; GOLD NANOSPHERES ; DOXORUBICIN ; NANOPARTICLES ; PACLITAXEL ; CISPLATIN ; DELIVERY ; XENOGRAFTS ; NANORODS ; PLATFORM |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000370094900015 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176559 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Yan; Nie, Guangjun |
| 作者单位 | Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Shishuai,Ding, Yanping,Li, Yiye,et al. Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triple-negative breast cancer[J]. Biomaterials,2016,80:169-178. |
| APA | Su, Shishuai,Ding, Yanping,Li, Yiye,Wu, Yan,&Nie, Guangjun.(2016).Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triple-negative breast cancer.Biomaterials,80,169-178. |
| MLA | Su, Shishuai,et al."Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triple-negative breast cancer".Biomaterials 80(2016):169-178. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。