In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care
文献类型：期刊论文
| 作者 | Dong, Rui-Hua1,2; Jia, Yue-Xiao2; Qin, Chong-Chong1; Zhan, Lu3; Yan, Xu1; Cui, Lin3; Zhou, Yu3; Jiang, Xingyu2; Long, Yun-Ze1,4 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2016-02-14 |
| 卷号 | 8期号:6页码:3482-3488 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c5nr08367b |
| 通讯作者 | Long, yun-ze(yunze.long@163.com) |
| 英文摘要 | Current strategies for wound care provide limited relief to millions of patients who suffer from burns, chronic skin ulcers or surgical-related wounds. the goal of this work is to develop an in situ deposition of a personalized nanofibrous dressing via a handy electrospinning (e-spinning) device and evaluate its properties related to skin wound care. mcm-41 type mesoporous silica nanoparticles decorated with silver nanoparticles (ag-msns) were prepared by a facile and environmentally friendly approach, which possessed long-term antibacterial activity and low cytotoxicity. poly-e-caprolactone (pcl) incorporated with ag-msns was successfully electrospun (e-spun) into nanofibrous membranes. these in situ e-spun nanofibrous membranes allowed the continuous release of ag ions and showed broad-spectrum antimicrobial activity against two common types of pathogens, staphylococcus aureus and escherichia coli. in addition, the in vivo studies revealed that these antibacterial nanofibrous membranes could reduce the inflammatory response and accelerate wound healing in wistar rats. the above results strongly demonstrate that such patient-specific dressings could be broadly applied in emergency medical transport, hospitals, clinics and at the patients' home in the near future. |
| WOS关键词 | NORMAL HUMAN KERATINOCYTES ; ANTIBACTERIAL ACTIVITY ; SILVER NANOPARTICLES ; BIOPOLYMER NANOFIBERS ; MATS ; BIOMATERIALS ; REGENERATION ; MEMBRANE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000369908900038 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176560 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Long, Yun-Ze |
| 作者单位 | 1.Qingdao Univ, Coll Phys, Collaborat Innovat Ctr Nanomat & Optoelect Device, Qingdao 266071, Peoples R China 2.Natl Ctr Nanosci & Technol, Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Qingdao Univ, Coll Med, Qingdao 266071, Peoples R China 4.Qingdao Univ, Collaborat Innovat Ctr Marine Biomass Fibers Mat, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Rui-Hua,Jia, Yue-Xiao,Qin, Chong-Chong,et al. In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care[J]. Nanoscale,2016,8(6):3482-3488. |
| APA | Dong, Rui-Hua.,Jia, Yue-Xiao.,Qin, Chong-Chong.,Zhan, Lu.,Yan, Xu.,...&Long, Yun-Ze.(2016).In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care.Nanoscale,8(6),3482-3488. |
| MLA | Dong, Rui-Hua,et al."In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care".Nanoscale 8.6(2016):3482-3488. |
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来源：高能物理研究所
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