Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles
文献类型：期刊论文
| 作者 | Zhang, Jiakun1,2; Liu, Yajing2; Zhao, Caiyan1; Cao, Lidong2; Huang, Qiliang2; Wu, Yan1 |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2016 |
| 卷号 | 16期号:1页码:152-159 |
| 关键词 | Co-delivery Nanoparticles Mpeg-plga Validamycin Hexaconazole |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2016.10674 |
| 通讯作者 | Huang, qiliang() ; Wu, yan() |
| 英文摘要 | Co-delivery system has been proposed in pharmaceutical field aim to synergistic treatments. the combination formulation is also important in traditional pesticides formulations based on the low pest resistance risk and wide fungicidal spectrum. however, co-delivery nanoparticles (nps) tend to be more environmentally friendly for the sustained-release behaviour and none of toxic organic solvents or dusts. hence, we constructed co-delivery nps which could delivery two kinds of pesticides, which function was similar with pesticides combination formulation. the co-delivery nps of validamycin and hexaconazole were prepared with the amphiphilic copolymer methoxy poly(ethylene glycol)poly(lactide-co-glycolide) (mpeg-plga) used an improved double emulsion method. the chemical structure of mpeg-plga copolymer was confirmed using fourier transform infrared spectroscopy (ft-ir), and nuclear magnetic resonance spectroscopy (nmr). the co-delivery nps all exhibited good size distribution and held sustained-release property. germicidal efficacy of the co-delivery nps against rhizoctonia cerealis was also studied. the germicidal efficacy of co-delivery nps against rhizoctonia cerealis was better than that of traditional pesticides formulation. in addition, co-delivery nps showed a lasting impact against rhizoctonia cerealis. |
| WOS关键词 | TARGETED DRUG-DELIVERY ; COPOLYMER NANOPARTICLES ; CONTROLLED-RELEASE ; PACLITAXEL ; DOXORUBICIN ; CELLS ; ACID ; HERBICIDES ; AVERMECTIN ; CHITOSAN |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000369680400011 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176563 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Huang, Qiliang; Wu, Yan |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 2.CAAS, Inst Plant Protect, MOA, Key Lab Pesticide Chem & Applicat, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jiakun,Liu, Yajing,Zhao, Caiyan,et al. Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles[J]. Journal of nanoscience and nanotechnology,2016,16(1):152-159. |
| APA | Zhang, Jiakun,Liu, Yajing,Zhao, Caiyan,Cao, Lidong,Huang, Qiliang,&Wu, Yan.(2016).Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles.Journal of nanoscience and nanotechnology,16(1),152-159. |
| MLA | Zhang, Jiakun,et al."Enhanced germicidal efficacy by co-delivery of validamycin and hexaconazole with methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) nanoparticles".Journal of nanoscience and nanotechnology 16.1(2016):152-159. |
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来源：高能物理研究所
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