Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells
文献类型：期刊论文
| 作者 | Deng, Xiongwei1,2; Wang, Yihui1; Zhang, Fang1; Yin, Zhaoxia1; Hu, Qin1; Xiao, Xiangqian1; Zhou, Zhixiang1; Wu, Yan2; Sheng, Wang1; Zeng, Yi1 |
| 刊名 | Chemical communications
 |
| 出版日期 | 2016 |
| 卷号 | 52期号:15页码:3243-3246 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c5cc10396g |
| 通讯作者 | Wu, yan(wuy@nanoctr.cn) ; Sheng, wang(shengwang@bjut.edu.cn) |
| 英文摘要 | Ph-induced charge-reversal nanoparticles incorporating microrna (mirna) were engineered through a single-step self-assembly of polyelectrolyte complexes. we found that the endosomal/lysosomal acidic environment could trigger the charge reversal of the nanoparticles from negative charge to positive charge and induce the structure alteration of the nanoparticles, which in turn led to accelerated endosomal escape and enhanced mirna modulation in esophageal cancer cells. |
| WOS关键词 | DRUG-DELIVERY ; HYBRID NANOPARTICLES ; SIRNA DELIVERY ; EXPRESSION ; TUMOR |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000370573400039 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176564 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Yan; Sheng, Wang |
| 作者单位 | 1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China 2.Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, 11 First North Rd, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Xiongwei,Wang, Yihui,Zhang, Fang,et al. Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells[J]. Chemical communications,2016,52(15):3243-3246. |
| APA | Deng, Xiongwei.,Wang, Yihui.,Zhang, Fang.,Yin, Zhaoxia.,Hu, Qin.,...&Zeng, Yi.(2016).Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells.Chemical communications,52(15),3243-3246. |
| MLA | Deng, Xiongwei,et al."Acidic ph-induced charge-reversal nanoparticles for accelerated endosomal escape and enhanced microrna modulation in cancer cells".Chemical communications 52.15(2016):3243-3246. |
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来源：高能物理研究所
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