An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer
文献类型：期刊论文
| 作者 | Ji, Tianjiao1,2; Li, Suping1,2; Zhang, Yinlong1,2,4; Lang, Jiayan1,2; Ding, Yanping1,2; Zhao, Xiao3; Zhao, Ruifang1,2; Li, Yiye1,2; Shi, Jian1,2; Hao, Jihui3 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2016-02-10 |
| 卷号 | 8期号:5页码:3438-3445 |
| 关键词 | Mmp-2 responsive liposome Antifibrosis Pancreatic stellate cells Enhanced drug perfusion Pancreatic cancer |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.5b11619 |
| 通讯作者 | Li, suping(lisuping@nanoctr.cn) ; Zhao, ying(zhaoying@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | Fibrotic stroma, a critical character of pancreatic tumor microenvironment, provides a critical barrier against the penetration and efficacy of various antitumor drugs. therefore, new strategies are urgently needed to alleviate the fibrotic mass and increase the drug perfusion within pancreatic cancer tissue. in our current work, we developed a,beta-cydodextrin (beta-cd) modified matrix metalloproteinase-2 (mmp-2) responsive liposome, integrating antifibrosis and chemotherapeutic drugs for regulation of pancreatic stellate cells (pscs), a key source of the fibrosis, and targeted delivery of cytotoxic drugs for pancreatic cancer therapy. these liposomes disassembed into two functional parts upon mmp-2 cleavage at the tumor site. one part was constituted by the beta-cds and the antifibrosis drug pirfenidone, which was kept in the stroma and inhibited the expression of collagen i and tgf-beta in pscs, down-regulating the fibrosis and decreasing the stromal barrier. the other segment, the rgd peptide-modified-liposome loading the chemotherapeutic drug gemcitabine, targeted and killed pancreatic tumor cells. this integrated nanomedicine, showing an increased drug perfusion without any overt side effects, may provide a potential strategy for improvement of the pancreatic cancer therapy. |
| WOS关键词 | STELLATE CELLS ; STROMAL BIOLOGY ; PHASE-III ; MICROENVIRONMENT ; GEMCITABINE ; THERAPY ; NANOPARTICLES ; PIRFENIDONE ; ACTIVATION ; DELIVERY |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000370211400063 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176565 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Suping; Zhao, Ying; Nie, Guangjun |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Tianjin Med Univ Canc Inst & Hosp, Dept Pancreat Carcinoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin 300060, Peoples R China 4.Jilin Univ, Coll Pharmaceut Sci, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Tianjiao,Li, Suping,Zhang, Yinlong,et al. An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer[J]. Acs applied materials & interfaces,2016,8(5):3438-3445. |
| APA | Ji, Tianjiao.,Li, Suping.,Zhang, Yinlong.,Lang, Jiayan.,Ding, Yanping.,...&Nie, Guangjun.(2016).An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer.Acs applied materials & interfaces,8(5),3438-3445. |
| MLA | Ji, Tianjiao,et al."An mmp-2 responsive liposome integrating antifibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer".Acs applied materials & interfaces 8.5(2016):3438-3445. |
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来源：高能物理研究所
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