Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding
文献类型：期刊论文
| 作者 | Wang, Shiwen1,2,3; Feng, Qiang1,2; Sun, Jiashu1,2; Gao, Feng1,2; Fan, Wei1,2; Zhang, Zhong1,2; Li, Xiaohong3; Jiang, Xingyu1,2 |
| 刊名 | Acs nano
 |
| 出版日期 | 2016 |
| 卷号 | 10期号:1页码:298-306 |
| 关键词 | Artificial joint Nanocrystalline cellulose Ultrahigh molecular weight polyethene Debris Friction |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.5b04393 |
| 通讯作者 | Sun, jiashu(sunjs@nanoctr.cn) ; Li, xiaohong(xhli@swjtu.edu.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | The doping of biocompatible nanomaterials into ultrahigh molecular weight polyethylene (uhmwpe) to improve the biocompatibility and reduce the wear debris is of great significance to prolonging implantation time of uhmwpe as the bearing material for artificial joints. this study shows that uhmwpe can form a composite with nanocrystalline cellulose (ncc, a hydrophilic nanosized material with a high aspect ratio) by ball-milling and hot-pressing. compared to pure uhmwpe, the ncc/uhmwpe composite exhibits improved tribological characteristics with reduced generation of wear debris. the underlying mechanism is related to the weak binding between hydrophilic ncc and hydrophobic uhmwpe. the hydrophilic, rigid ncc particles tend to detach from the uhmwpe surface during friction, which could move with the rubbing surface, serve as a thin lubricant layer, and protect the uhmwpe substrate from abrasion. the biological safety of the ncc/uhmwpe composite, as tested by mc3t3-e1 preosteoblast cells and macrophage raw264.7 cells, is high, with significantly lower inflammatory responses/cytotoxicity than pure uhmwpe. the ncc/uhmwpe composite therefore could be a promising alternative to the current uhmwpe for bearing applications. |
| WOS关键词 | CARBON NANOTUBES ; IN-VITRO ; SIZE ; NANOCOMPOSITES ; NANOPARTICLES ; BIOMATERIALS ; PARTICLES ; MECHANISM ; NANOPAPER ; FUTURE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000369115800030 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176568 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Sun, Jiashu; Li, Xiaohong; Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ China, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Shiwen,Feng, Qiang,Sun, Jiashu,et al. Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding[J]. Acs nano,2016,10(1):298-306. |
| APA | Wang, Shiwen.,Feng, Qiang.,Sun, Jiashu.,Gao, Feng.,Fan, Wei.,...&Jiang, Xingyu.(2016).Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding.Acs nano,10(1),298-306. |
| MLA | Wang, Shiwen,et al."Nanocrystalline cellulose improves the biocompatibility and reduces the wear debris of ultrahigh molecular weight polyethylene via weak binding".Acs nano 10.1(2016):298-306. |
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