The biocompatibility evaluation of iron oxide nanoparticles synthesized by a one pot process for intravenous iron supply
文献类型：期刊论文
| 作者 | Li, Juanjuan1,2,3; Liu, Yang1,2,3; Cha, Ruitao1,2; Ran, Bei1,2,4; Mou, Kaiwen1,2,5; Wang, Huashan3; Xie, Qian6; Sun, Jiashu1,2; Jiang, Xingyu1,2 |
| 刊名 | Rsc advances
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:17页码:14329-14334 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c5ra25729h |
| 通讯作者 | Li, juanjuan(chart@nanoctr.cn) ; Xie, qian(xieqian_2001@hotmail.com) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | This paper reports a new synthesis method to control the size of iron oxide nanoparticles (ions) by adding sodium citrate during fabrication to obtain sodium citrate-modified iron oxide nanoparticles (scions). the method was simpler and more effective than the synthetic process of ferumoxytol, a commercial nanosized iron agent. compared with other iron agents which were prepared using branched polymers to form a carbohydrate shell, our scions were tightly bound within a nonionic carbohydrate matrix. the physicochemical properties of scions were characterized, and the results showed that these nanoparticles could be stably stored in water for six months without sedimentation. the cytotoxicity evaluation of scions indicated that they were biocompatible to cells. the effect of iron supply by scions was assessed by measuring the retention of iron ions in the serum, and the results demonstrated that the synthesized scions are very promising for intravenous iron supply. |
| WOS关键词 | CHRONIC KIDNEY-DISEASE ; HIGH-RESOLUTION ; FE3O4 NANOPARTICLES ; OXIDATIVE STRESS ; SODIUM-CITRATE ; UNITED-STATES ; MOUSE BRAINS ; ORAL IRON ; FERUMOXYTOL ; THERAPY |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000369639400091 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176572 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Juanjuan; Xie, Qian; Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Tianjin Univ Sci & Technol, Sch Chem Engn & Mat Sci, Tianjin 300457, Peoples R China 4.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China 5.Ocean Univ China, Coll Mat Sci & Engn, Qingdao 266100, Peoples R China 6.Peking Univ, Hosp 3, Div Nephrol, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Juanjuan,Liu, Yang,Cha, Ruitao,et al. The biocompatibility evaluation of iron oxide nanoparticles synthesized by a one pot process for intravenous iron supply[J]. Rsc advances,2016,6(17):14329-14334. |
| APA | Li, Juanjuan.,Liu, Yang.,Cha, Ruitao.,Ran, Bei.,Mou, Kaiwen.,...&Jiang, Xingyu.(2016).The biocompatibility evaluation of iron oxide nanoparticles synthesized by a one pot process for intravenous iron supply.Rsc advances,6(17),14329-14334. |
| MLA | Li, Juanjuan,et al."The biocompatibility evaluation of iron oxide nanoparticles synthesized by a one pot process for intravenous iron supply".Rsc advances 6.17(2016):14329-14334. |
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