Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs
文献类型：期刊论文
| 作者 | Zhang, Mei1; Song, Cheng-Cheng1; Ji, Ran1; Qiao, Zeng-Ying2; Yang, Chao2; Qiu, Fang-Yi1; Liang, De-Hai1; Du, Fu-Sheng1; Li, Zi-Chen1 |
| 刊名 | Polymer chemistry
 |
| 出版日期 | 2016 |
| 卷号 | 7期号:7页码:1494-1504 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c5py01999k |
| 通讯作者 | Du, fu-sheng(fsdu@pku.edu.cn) ; Li, zi-chen(zcli@pku.edu.cn) |
| 英文摘要 | Oxidation stress has been becoming an important target for the development of smart nanomedicines, triggering research interest in oxidation responsive polymers. herein, we report a new type of temperature/ oxidation dual responsive copolymer. they were synthesized by the sequential atom transfer radical copolymerization (atrp) of n-isopropylacrylamide (nipam, m1) and a phenylboronic pinacol estercontaining acrylate (m2) and dialysis against water to remove the pinacol protecting groups. the copolymers with a small amount of phenylboronic acid units (< 7%) were soluble in cold neutral phosphate buffer but showed lower critical solution temperatures in the range of 12-31 degrees c. the thermally induced phase transition profiles depended on both the composition and concentration of the polymers. the cloud points of the copolymers were shifted to higher temperatures upon h2o2 induced oxidation of the phenylboronic acid and the subsequent 1,6-elimination. using peg-cl as the macroinitiator to initiate atrp of m1 and m2, three block copolymers composed of a peg block and a temperature/oxidation dual responsive segment were prepared after dialysis in water. these block copolymers had a similar ratio of nipam to phenylboronic acid units but different molecular weights. we have studied their thermal selfassembly and h2o2 triggered decomposition by laser light scattering, h-1 nmr, and transmission electron microscopy. upon a fast heating protocol, these block copolymers formed stable micelle-like nanoparticles (at 37 degrees c) that were capable of encapsulating doxorubicin (dox) and showed h2o2 triggered release. the naked nanoparticles were cytocompatible, however the dox-loaded ones exhibited concentration dependent cytotoxicity, in particular to cancer cells. |
| WOS关键词 | CYCLIC ORTHOESTER GROUPS ; REACTIVE OXYGEN ; DRUG-DELIVERY ; BLOCK-COPOLYMERS ; POLY(ETHYLENE GLYCOL) ; HYDROGEN-PEROXIDE ; BIOMEDICAL APPLICATIONS ; AQUEOUS-SOLUTIONS ; POLY(N-ISOPROPYLACRYLAMIDE) ; NANOPARTICLES |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000369692700016 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176573 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Du, Fu-Sheng; Li, Zi-Chen |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys,Minist Educ, Ctr Soft Matter Sci & Engn,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Mei,Song, Cheng-Cheng,Ji, Ran,et al. Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs[J]. Polymer chemistry,2016,7(7):1494-1504. |
| APA | Zhang, Mei.,Song, Cheng-Cheng.,Ji, Ran.,Qiao, Zeng-Ying.,Yang, Chao.,...&Li, Zi-Chen.(2016).Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs.Polymer chemistry,7(7),1494-1504. |
| MLA | Zhang, Mei,et al."Oxidation and temperature dual responsive polymers based on phenylboronic acid and n-isopropylacrylamide motifs".Polymer chemistry 7.7(2016):1494-1504. |
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