A high-throughput platform for formulating and screening multifunctional nanoparticles capable of simultaneous delivery of genes and transcription factors
文献类型：期刊论文
| 作者 | Liu, Yang1,2,3; Du, Juanjuan3; Choi, Jin-sil4; Chen, Kuan-Ju4; Hou, Shuang4; Yan, Ming3; Lin, Wei-Yu5; Chen, Kevin Sean4; Ro, Tracy4; Lipshutz, Gerald S.6 |
| 刊名 | Angewandte chemie-international edition
 |
| 出版日期 | 2016-01-04 |
| 卷号 | 55期号:1页码:169-173 |
| 关键词 | Biomolecular delivery Microfluidics Nanoparticles Supramolecular chemistry Transcription factors |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201507546 |
| 通讯作者 | Lu, yunfeng(luucla@ucla.edu) |
| 英文摘要 | Simultaneous delivery of multiple genes and proteins (e.g., transcription factors; tfs) is an emerging issue surrounding therapeutic research due to their ability to regulate cellular circuitry. current gene and protein delivery strategies, however, are based on slow batch synthesis, which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and proteins with synergistic functions. consequently, advances in this field have been limited to in vitro studies. here, by integrating microfluidic technologies with a supramolecular synthetic strategy, we present a high-throughput approach for formulating and screening multifunctional supramolecular nanoparticles (mfsnps) self-assembled from a collection of functional modules to achieve simultaneous delivery of one gene and tf with unprecedented efficiency both in vitro and in vivo. we envision that this new approach could open a new avenue for immunotherapy, stem cell reprogramming, and other therapeutic applications. |
| 收录类别 | SCI |
| WOS关键词 | SUPRAMOLECULAR NANOPARTICLES ; INTEGRATED MICROFLUIDICS ; GOLD NANOPARTICLES ; CANCER ; GENERATION ; CHEMISTRY ; COPOLYMER ; LIBRARY ; SYSTEMS ; CELLS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000368065300012 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176577 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Lu, Yunfeng |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Nanosci & Technol NCNST, Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China 2.Nankai Univ, Inst Polymer Chem, State Key Lab Med Chem Biol, Key Lab Funct Polymer Mat,Minist Educ, Tianjin 300071, Peoples R China 3.UCLA, Calif NanoSyst Inst, Dept Biomol & Chem Engn, Los Angeles, CA 90095 USA 4.Univ Calif Los Angeles, Calif NanoSyst Inst, Crump Inst Mol Imaging, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA 5.Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 80708, Taiwan 6.UCLA, David Geffen Sch Med, Dept Surg, Div Liver & Pancreas Transplantat, Los Angeles, CA USA |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Du, Juanjuan,Choi, Jin-sil,et al. A high-throughput platform for formulating and screening multifunctional nanoparticles capable of simultaneous delivery of genes and transcription factors[J]. Angewandte chemie-international edition,2016,55(1):169-173. |
| APA | Liu, Yang.,Du, Juanjuan.,Choi, Jin-sil.,Chen, Kuan-Ju.,Hou, Shuang.,...&Wang, Hao.(2016).A high-throughput platform for formulating and screening multifunctional nanoparticles capable of simultaneous delivery of genes and transcription factors.Angewandte chemie-international edition,55(1),169-173. |
| MLA | Liu, Yang,et al."A high-throughput platform for formulating and screening multifunctional nanoparticles capable of simultaneous delivery of genes and transcription factors".Angewandte chemie-international edition 55.1(2016):169-173. |
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