Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation
文献类型：期刊论文
| 作者 | Ji, Tianjiao1; Zhao, Ying1; Ding, Yanping1; Wang, Jing1; Zhao, Ruifang1; Lang, Jiayan1; Qin, Hao1; Liu, Xiaoman2; Shi, Jian1; Tao, Ning2 |
| 刊名 | Angewandte chemie-international edition
 |
| 出版日期 | 2016-01-18 |
| 卷号 | 55期号:3页码:1050-1055 |
| 关键词 | Cancer-associated fibroblasts Drug delivery Fibroblast activation protein-alpha Morphological transformation Peptide assembly |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201506262 |
| 通讯作者 | Zhao, yuliang(zhaoyl@nanoctr.cn) |
| 英文摘要 | A novel cleavable amphiphilic peptide (cap) was designed to be specifically responsive to fibroblast activation protein- (fap-), a protease specifically expressed on the surface of cancer-associated fibroblasts. the cap self-assembled into fiber-like nanostructures in solution, while the presence of hydrophobic chemotherapeutic drugs readily transformed the assemblies into drug-loaded spherical nanoparticles. the disassembly of these nanoparticles (cap-nps) upon fap- cleavage resulted in rapid and efficient release of the encapsulated drugs specifically at tumor sites. this transformers-like drug delivery strategy could allow them to disrupt the stromal barrier and enhance local drug accumulation. therapeutic results suggested that drug-loaded cap-nps hold promising tumor specificity and therapeutic efficacy for various solid tumor models, confirming its potential utility and versatility in antitumor therapy. |
| WOS关键词 | STROMAL FIBROBLASTS ; SERINE-PROTEASE ; SURFACE-CHARGE ; NANOPARTICLES ; DELIVERY ; TUMORS ; PH ; HETEROGENEITY ; NANOMEDICINE ; SPECIFICITY |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000368070000036 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176579 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, Yuliang |
| 作者单位 | 1.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Inst Biophys, CAS Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Tianjiao,Zhao, Ying,Ding, Yanping,et al. Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation[J]. Angewandte chemie-international edition,2016,55(3):1050-1055. |
| APA | Ji, Tianjiao.,Zhao, Ying.,Ding, Yanping.,Wang, Jing.,Zhao, Ruifang.,...&Zhao, Yuliang.(2016).Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation.Angewandte chemie-international edition,55(3),1050-1055. |
| MLA | Ji, Tianjiao,et al."Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation".Angewandte chemie-international edition 55.3(2016):1050-1055. |
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来源：高能物理研究所
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