An experimental and computational approach to the development of zno nanoparticles that are safe by design
文献类型：期刊论文
| 作者 | Le, Tu C.1; Yin, Hong1; Chen, Rui2,3; Chen, Yandong2,3; Zhao, Lin2,3; Casey, Philip S.1; Chen, Chunying2,3; Winkler, David A.1,4,5,6 |
| 刊名 | Small
 |
| 出版日期 | 2016-07-13 |
| 卷号 | 12期号:26页码:3568-3577 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201600597 |
| 通讯作者 | Chen, chunying(chenchy@nanoctr.cn) ; Winkler, david a.(dave.winkler@csiro.au) |
| 英文摘要 | Zinc oxide nanoparticles have found wide application due to their unique optoelectronic and photocatalytic characteristics. however, their safety aspects remain of critical concern, prompting the use of physicochemical modifications of pristine zno to reduce any potential toxicity. however, the relationships between these modifications and their effects on biology are complex and still relatively unexplored. to address this knowledge gap, a library of 45 types of zno nanoparticles with varying particle size, aspect ratio, doping type, doping concentration, and surface coating is synthesized, and their biological effects measured. three biological assays measuring cell damage or stress are used to study the responses of human umbilical vein endothelial cells (huvecs) or human hepatocellular liver carcinoma cells (hepg2) to the nanoparticles. these experimental data are used to develop quantitative and predictive computational models linking nanoparticle properties to cell viability, membrane integrity, and oxidative stress. it is found that the concentration of nanoparticles the cells are exposed to, the type of surface coating, the nature and extent of doping, and the aspect ratio of the particles make significant contributions to the cell toxicity of the nanoparticles tested. our study shows that it is feasible to generate models that could be used to design or optimize nanoparticles with commercially useful properties that are also safe to humans and the environment. |
| WOS关键词 | ZINC-OXIDE NANOPARTICLES ; OXIDATIVE STRESS ; DESCRIPTOR SELECTION ; CYTOTOXICITY ; CELLS ; QSAR ; TOXICITY ; NANOTECHNOLOGY ; NANOTOXICOLOGY ; NANOMATERIALS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000383374600011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176581 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Chunying; Winkler, David A. |
| 作者单位 | 1.CSIRO Mfg, Bayview Ave, Clayton, Vic 3168, Australia 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 4.Monash Inst Pharmaceut Sci, 381 Royal Parade, Parkville, Vic 3052, Australia 5.La Trobe Univ, Latrobe Inst Mol Sci, Bundoora, Vic 3046, Australia 6.Flinders Univ S Australia, Sch Chem & Phys Sci, Bedford Pk, SA 5042, Australia |
| 推荐引用方式 GB/T 7714 | Le, Tu C.,Yin, Hong,Chen, Rui,et al. An experimental and computational approach to the development of zno nanoparticles that are safe by design[J]. Small,2016,12(26):3568-3577. |
| APA | Le, Tu C..,Yin, Hong.,Chen, Rui.,Chen, Yandong.,Zhao, Lin.,...&Winkler, David A..(2016).An experimental and computational approach to the development of zno nanoparticles that are safe by design.Small,12(26),3568-3577. |
| MLA | Le, Tu C.,et al."An experimental and computational approach to the development of zno nanoparticles that are safe by design".Small 12.26(2016):3568-3577. |
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