Evaluation of the differences of myocardial fibers between acute and chronic myocardial infarction: application of diffusion tensor magnetic resonance imaging in a rhesus monkey model
文献类型：期刊论文
| 作者 | Wang, Yuqing1,2; Cai, Wei1,3; Wang, Lei1; Xia, Rui1,4; Chen, Wei1,5; Zheng, Jie6; Gao, Fabao1 |
| 刊名 | Korean journal of radiology
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 17期号:5页码:725-733 |
| ISSN号 | 1229-6929 |
| 关键词 | Rhesus monkey Myocardial fiber Myocardial infarction Helix angle Diffusion tensor mr imaging Dti |
| DOI | 10.3348/kjr.2016.17.5.725 |
| 通讯作者 | Gao, fabao(gaofabao_sub@163.com) |
| 英文摘要 | Objective: to understand microstructural changes after myocardial infarction (mi), we evaluated myocardial fibers of rhesus monkeys during acute or chronic mi, and identified the differences of myocardial fibers between acute and chronic mi. materials and methods: six fixed hearts of rhesus monkeys with left anterior descending coronary artery ligation for 1 hour or 84 days were scanned by diffusion tensor magnetic resonance imaging (mri) to measure apparent diffusion coefficient (adc), fractional anisotropy (fa) and helix angle (ha). results: comparing with acute mi monkeys (fa: 0.59 +/- 0.02; adc: 5.0 +/- 0.6 x 10(-4) mm(2)/s; ha: 94.5 +/- 4.4 degrees), chronic mi monkeys showed remarkably decreased fa value (0.26 +/- 0.03), increased adc value (7.8 +/- 0.8 x 10(-4)mm(2)/s), decreased ha transmural range (49.5 +/- 4.6 degrees) and serious defects on endocardium in infarcted regions. the ha in infarcted regions shifted to more components of negative left-handed helix in chronic mi monkeys (-38.3 +/- 5.0 degrees-11.2 +/- 4.3 degrees) than in acute mi monkeys (-41.4 +/- 5.1 degrees-53.1 +/- 3.7 degrees), but the ha in remote regions shifted to more components of positive right-handed helix in chronic mi monkeys (-43.8 +/- 2.7 degrees-66.5 +/- 4.9 degrees) than in acute mi monkeys (-59.5 +/- 3.4 degrees-64.9 +/- 4.3 degrees). conclusion: diffusion tensor mri method helps to quantify differences of mechanical microstructure and water diffusion of myocardial fibers between acute and chronic mi monkey's models. |
| WOS关键词 | HYPERTROPHIC CARDIOMYOPATHY ; TRANSMURAL HETEROGENEITY ; HISTOLOGICAL VALIDATION ; LAMINAR STRUCTURE ; PORCINE MODEL ; WALL-MOTION ; HEART ; MRI ; ARCHITECTURE ; ANISOTROPY |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | KOREAN RADIOLOGICAL SOC |
| WOS记录号 | WOS:000383357700016 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176582 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gao, Fabao |
| 作者单位 | 1.Sichuan Univ, West China Hosp, Dept Radiol, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Peking Univ, Clin Med Coll 4, Beijing Jishuitan Hosp, Dept Radiol, Beijing 100035, Peoples R China 4.Chongqing Med Univ, Affiliated Hosp 3, Dept Radiol, Chongqing 400016, Peoples R China 5.Kunming Med Univ, Affiliated Hosp 1, Dept Radiol, Kunming 650032, Yunnan, Peoples R China 6.Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA |
| 推荐引用方式 GB/T 7714 | Wang, Yuqing,Cai, Wei,Wang, Lei,et al. Evaluation of the differences of myocardial fibers between acute and chronic myocardial infarction: application of diffusion tensor magnetic resonance imaging in a rhesus monkey model[J]. Korean journal of radiology,2016,17(5):725-733. |
| APA | Wang, Yuqing.,Cai, Wei.,Wang, Lei.,Xia, Rui.,Chen, Wei.,...&Gao, Fabao.(2016).Evaluation of the differences of myocardial fibers between acute and chronic myocardial infarction: application of diffusion tensor magnetic resonance imaging in a rhesus monkey model.Korean journal of radiology,17(5),725-733. |
| MLA | Wang, Yuqing,et al."Evaluation of the differences of myocardial fibers between acute and chronic myocardial infarction: application of diffusion tensor magnetic resonance imaging in a rhesus monkey model".Korean journal of radiology 17.5(2016):725-733. |
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