In situ construction and characterization of chlorin-based supramolecular aggregates in tumor cells
文献类型：期刊论文
| 作者 | Liu, Wei-Jiao1,2; Zhang, Di2; Li, Li-Li2; Qiao, Zen-Ying2; Zhang, Ju-Chen1; Zhao, Ying-Xi2; Qi, Guo-Bin2; Wan, Dong1; Pan, Jie1; Wang, Hao2 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2016-09-07 |
| 卷号 | 8期号:35页码:22875-22883 |
| 关键词 | Supramolecular Chlorin Ph sensitive Tumor Photoacoustic imaging |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b07049 |
| 通讯作者 | Pan, jie(panjie@tjpu.edu.cn) ; Wang, hao(wanghao@nanoctr.cn) |
| 英文摘要 | We demonstrate in situ construction and characterization of supramolecular aggregates from chlorin p6 (cp6) molecules in tumor cells. fully deprotonated cp6 molecules in neutral condition were partially protonated inside the acidic lysosomes of cells and significantly increased the hydrophobicity of them that resulted in simultaneous formation of j-type aggregates. importantly, the formation of j-aggregates was fully characterized in artificial tissues by uv-vis, circular dichroism (cd) and transmission electron microscope (tem) techniques. compared to the monomers, the j-aggregates exhibited 55-fold enhanced thermal conversion efficiency (eta) at the optimal excitation wavelength (690 nm). the remarkably increased heat effect contributed to the stronger photoacoustic (pa) signals, leading to at least 2 orders of magnitude increase of the tumor-to-normal tissue ratio (tin), which was defined as the pa signal ratio between tumor site and surrounding normal tissue. we envision that this proof-of-concept study will open a new way to develop tumor environment-induced-self-assembly for variable biomedical applications. |
| WOS关键词 | DRUG-DELIVERY ; CANCER-CELLS ; SELF-ORGANIZATION ; CARBON NANOTUBES ; IMAGING PROBES ; LIVING MICE ; LIVE CELLS ; VIVO ; NANOPARTICLES ; NANOSTRUCTURES |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000382902800017 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176584 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Pan, Jie; Wang, Hao |
| 作者单位 | 1.Tianjin Polytech Univ, State Key Lab Hollow Fiber Membrane Mat & Proc, Sch Environm & Chem Engn, Tianjin 100044, Peoples R China 2.Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Wei-Jiao,Zhang, Di,Li, Li-Li,et al. In situ construction and characterization of chlorin-based supramolecular aggregates in tumor cells[J]. Acs applied materials & interfaces,2016,8(35):22875-22883. |
| APA | Liu, Wei-Jiao.,Zhang, Di.,Li, Li-Li.,Qiao, Zen-Ying.,Zhang, Ju-Chen.,...&Wang, Hao.(2016).In situ construction and characterization of chlorin-based supramolecular aggregates in tumor cells.Acs applied materials & interfaces,8(35),22875-22883. |
| MLA | Liu, Wei-Jiao,et al."In situ construction and characterization of chlorin-based supramolecular aggregates in tumor cells".Acs applied materials & interfaces 8.35(2016):22875-22883. |
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来源：高能物理研究所
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