Carboxymethyl dextran-stabilized polyethylenimine-poly(epsilon-caprolactone) nanoparticles-mediated modulation of microrna-34a expression via small-molecule modulator for hepatocellular carcinoma therapy
文献类型：期刊论文
| 作者 | Deng, Xiongwei1,2; Yin, Zhaoxia1; Zhou, Zhixiang1; Wang, Yihui1; Zhang, Fang1; Hu, Qin1; Yang, Yishu1; Lu, Jianqing2; Wu, Yan2; Sheng, Wang1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2016-07-13 |
| 卷号 | 8期号:27页码:17068-17079 |
| 关键词 | Carboxymethyl dextran Polyethylenimine-poly(epsilon-caprolactone) Nanoparticles Microrna modulation Small-molecule modulator Hepatocellular carcinoma |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b03122 |
| 通讯作者 | Wu, yan(wuy@nanoctr.cn) ; Sheng, wang(shengwang@bjut.edu.cn) |
| 英文摘要 | Microrna-34a (mir-34a) modulation therapy has shown great promise to treat hepatocellular carcinoma (hcc). 2'-hydroxy-2,4,4',5,6'-pentamethoxychalcone, termed rubone, has been shown to specifically upregulate mir-34a expression in hcc cells and considered as novel anticancer agent. however, the extremely low aqueous solubility of rubone hampers its use in cancer treatment. in the present study, surface-stabilized nanoparticles-based delivery strategy was engaged to overcome this impediment. in our preparation, rubone was encapsulated in the micelles composed of polyethylenimine-poly(epsilon-caprolactone) (pei-pcl) through hydrophobic interactions, which were subsequently stabilized with anionic carboxymethyl dextran cmd via electronic interaction. we found that rubone-encapsulating nanoparticles are dispersed well in aqueous solution. the results further demonstrated that rubone could be efficiently delivered in hcc cells by nanoparticles and upregulate mir-34a expression, which in turn led to inhibition of proliferation, migration, and increased apoptosis of hcc cells. in vivo experiments showed that rubone can be preferentially delivered into tumor tissues by cmd-stabilized pei-pcl nanoparticles after intravenous administration and significantly inhibited tumor growth. furthermore, low cytotoxicity of the nanoparticles was observed in vitro and in vivo analyses, indicating a good compatibility of generated nanoparticles. the obtained results suggest that cmd-stabilized pei-pcl nanoparticles may serve as a novel approach for small-molecule-modulator mediated mir-34a restoration for hcc therapy. |
| WOS关键词 | NEGATIVE BREAST-CANCER ; DRUG-DELIVERY ; POLYMERIC NANOPARTICLES ; INTRACELLULAR DELIVERY ; IN-VIVO ; ACID ; PH ; NANOMATERIALS ; BINDING ; DESIGN |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000379794100009 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176598 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Yan; Sheng, Wang |
| 作者单位 | 1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Xiongwei,Yin, Zhaoxia,Zhou, Zhixiang,et al. Carboxymethyl dextran-stabilized polyethylenimine-poly(epsilon-caprolactone) nanoparticles-mediated modulation of microrna-34a expression via small-molecule modulator for hepatocellular carcinoma therapy[J]. Acs applied materials & interfaces,2016,8(27):17068-17079. |
| APA | Deng, Xiongwei.,Yin, Zhaoxia.,Zhou, Zhixiang.,Wang, Yihui.,Zhang, Fang.,...&Zeng, Yi.(2016).Carboxymethyl dextran-stabilized polyethylenimine-poly(epsilon-caprolactone) nanoparticles-mediated modulation of microrna-34a expression via small-molecule modulator for hepatocellular carcinoma therapy.Acs applied materials & interfaces,8(27),17068-17079. |
| MLA | Deng, Xiongwei,et al."Carboxymethyl dextran-stabilized polyethylenimine-poly(epsilon-caprolactone) nanoparticles-mediated modulation of microrna-34a expression via small-molecule modulator for hepatocellular carcinoma therapy".Acs applied materials & interfaces 8.27(2016):17068-17079. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。