Fully zwitterionic nanoparticle antimicrobial agents through tuning of core size and ligand structure
文献类型：期刊论文
| 作者 | Huo, Shuaidong1,2,3,4; Jiang, Ying1; Gupta, Akash1; Jiang, Ziwen1; Landis, Ryan F.1; Hou, Singyuk1; Liang, Xing-Jie2,3,4; Rotello, Vincent M.1 |
| 刊名 | Acs nano
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 10期号:9页码:8732-8737 |
| 关键词 | Antimicrobial activity Size Charge orientation Zwitterionic gold nanoparticles |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.6b04207 |
| 通讯作者 | Liang, xing-jie(liangxj@nanoctr.cn) ; Rotello, vincent m.(rotello@chem.umass.edu) |
| 英文摘要 | Zwitterionic nanoparticles are generally considered nontoxic and noninteracting. here, we report effective and selective antimicrobial activity of zwitterionic gold nanoparticles (aunp) through modulation np size and surface charge orientation. using a set of 2, 4, and 6 nm core aunps, increasing particle size increased antimicrobial efficiency through bacterial membrane disruption. further improvement was observed through control of the ligand structure, generating antimicrobial particles with low hemolytic activity and demonstrating the importance of size and surface structure in dictating the bioactivity properties of nanomaterials. |
| WOS关键词 | ULTRASMALL GOLD NANOPARTICLES ; GRAM-NEGATIVE BACTERIA ; CATIONIC NANOPARTICLES ; ANTIBACTERIAL ACTIVITY ; HEMOLYTIC-ACTIVITY ; GROWTH-INHIBITION ; CELLULAR UPTAKE ; ZINC-OXIDE ; SURFACES ; TOXICITY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000384399300067 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176651 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liang, Xing-Jie; Rotello, Vincent M. |
| 作者单位 | 1.Univ Massachusetts, Dept Chem, 710 North Pleasant St, Amherst, MA 01003 USA 2.Chinese Acad Sci, Ctr Excellence Nanosci, Lab Controllable Nanopharmaceut, First North Rd, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, First North Rd, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huo, Shuaidong,Jiang, Ying,Gupta, Akash,et al. Fully zwitterionic nanoparticle antimicrobial agents through tuning of core size and ligand structure[J]. Acs nano,2016,10(9):8732-8737. |
| APA | Huo, Shuaidong.,Jiang, Ying.,Gupta, Akash.,Jiang, Ziwen.,Landis, Ryan F..,...&Rotello, Vincent M..(2016).Fully zwitterionic nanoparticle antimicrobial agents through tuning of core size and ligand structure.Acs nano,10(9),8732-8737. |
| MLA | Huo, Shuaidong,et al."Fully zwitterionic nanoparticle antimicrobial agents through tuning of core size and ligand structure".Acs nano 10.9(2016):8732-8737. |
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来源：高能物理研究所
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