Photonic crystal fiber-based immunosensor for high-performance detection of alpha fetoprotein
文献类型：期刊论文
| 作者 | Liu, Xiaoxia1; Song, Xingda1; Dong, Zhiyong2,3; Meng, Xiaoting2,3; Chen, Yiping4,5; Yang, Li1 |
| 刊名 | Biosensors & bioelectronics
 |
| 出版日期 | 2017-05-15 |
| 卷号 | 91页码:431-435 |
| 关键词 | Photonic crystal fiber Immunosensor Cancer biomarker detection |
| ISSN号 | 0956-5663 |
| DOI | 10.1016/j.bios.2016.12.058 |
| 通讯作者 | Chen, yiping(chenyp@nanoctr.cn) ; Yang, li(yangl330@nenu.edu.cn) |
| 英文摘要 | We have developed a sensitive photonic crystal fiber (pcf)-based immunosensor for detection of alpha fetoprotein (afp). the unique pcf possesses a morphology characterized by numerous pore structures and a large surface area-to-volume ratio, which can be used as an immune-reaction carrier to improve the sensitivity and reaction speed of afp detection. the pcf-based immunosensor possesses a low limit of detection of 0.1 ng/ml, which is five times lower than that of the capillary-based sensor and 35 times lower than that of the traditional enzyme-linked immunosorbent assay. the wide linear dynamic range of 0.1-150 ng/ml makes the developed immunosensor suitable for clinical practice. the proposed method was successfully applied to afp detection in a clinical serum sample with acceptable precision. it is indicated that the present pcf-based immunosensor could be used as an attractive analytical platform for sensitive and specific detection of cancer biomarkers. |
| WOS关键词 | LASER-INDUCED FLUORESCENCE ; ELECTROCHEMICAL IMMUNOSENSOR ; CLINICAL-APPLICATIONS ; SIGNAL AMPLIFICATION ; BIOMARKER DETECTION ; TUMOR-MARKERS ; IMMUNOASSAY ; NANOPARTICLES ; SENSORS ; DEVICE |
| WOS研究方向 | Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics |
| WOS类目 | Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology |
| 语种 | 英语 |
| WOS记录号 | WOS:000395599000063 |
| 出版者 | ELSEVIER ADVANCED TECHNOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176675 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Yiping; Yang, Li |
| 作者单位 | 1.Northeast Normal Univ, Key Lab Nanobiosensing & Nanobioanal Univ Jilin P, Dept Chem, 5268 Renmin St, Changchun 130024, Jilin Province, Peoples R China 2.Jilin Univ, Dept Histol, Basic Med Coll, Changchun 130021, Peoples R China 3.Jilin Univ, Dept Embryol, Basic Med Coll, Changchun 130021, Peoples R China 4.Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 5.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiaoxia,Song, Xingda,Dong, Zhiyong,et al. Photonic crystal fiber-based immunosensor for high-performance detection of alpha fetoprotein[J]. Biosensors & bioelectronics,2017,91:431-435. |
| APA | Liu, Xiaoxia,Song, Xingda,Dong, Zhiyong,Meng, Xiaoting,Chen, Yiping,&Yang, Li.(2017).Photonic crystal fiber-based immunosensor for high-performance detection of alpha fetoprotein.Biosensors & bioelectronics,91,431-435. |
| MLA | Liu, Xiaoxia,et al."Photonic crystal fiber-based immunosensor for high-performance detection of alpha fetoprotein".Biosensors & bioelectronics 91(2017):431-435. |
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来源：高能物理研究所
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