Peptide-au clusters induced tumor cells apoptosis via targeting glutathione peroxidase-1: the molecular dynamics assisted experimental studies
文献类型：期刊论文
| 作者 | Liu, Meiqing1,2; Gao, Liang1; Zhao, Lina1; He, Jian1; Yuan, Qing1; Zhang, Peng1; Zhao, Yawei1; Gao, Xueyun1,3 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2017-03-09 |
| 卷号 | 7页码:10 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-00278-6 |
| 通讯作者 | Gao, liang(gaoliang@ihep.ac.cn) ; Zhao, lina(linazhao@ihep.ac.cn) ; Gao, xueyun(gaoxy@ihep.ac.cn) |
| 英文摘要 | The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. glutathione peroxidase-1 (gpx-1) is a crucial antioxidant selenoenzyme that regulates cellular redox level, thus becomes a potential target in cancer treatment. we firstly utilize molecular dynamic ( md) simulation to rationally design and screen serial peptide-au cluster compounds with special peptide sequences and precise gold atoms, which can recognize and bind specific domain of gpx-1 with high affinity. the theoretical simulations were further verified by the following peptide-au clusters synthesis and gpx-1 activity suppression studies in buffer and cells, respectively. further cytological experiments corroborated that peptide-au clusters are promising nanoparticles inducing tumor cells apoptosis by suppressing gpx-1 activity and increasing higher cellular reactive oxygen species level to initiate tumor cell apoptosis through intrinsic mitochondrial pathway. |
| WOS关键词 | PROTEIN-NANOPARTICLE INTERACTIONS ; MEDIATED MITOCHONDRIAL PATHWAY ; METAL NANOCLUSTERS ; OPTICAL-PROPERTIES ; CHEMICAL-SYNTHESIS ; GOLD NANOCLUSTERS ; ATOMIC PRECISION ; QUANTUM DOTS ; CANCER-CELLS ; INHIBITION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000396868900013 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176682 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gao, Liang; Zhao, Lina; Gao, Xueyun |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100124, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Meiqing,Gao, Liang,Zhao, Lina,et al. Peptide-au clusters induced tumor cells apoptosis via targeting glutathione peroxidase-1: the molecular dynamics assisted experimental studies[J]. Scientific reports,2017,7:10. |
| APA | Liu, Meiqing.,Gao, Liang.,Zhao, Lina.,He, Jian.,Yuan, Qing.,...&Gao, Xueyun.(2017).Peptide-au clusters induced tumor cells apoptosis via targeting glutathione peroxidase-1: the molecular dynamics assisted experimental studies.Scientific reports,7,10. |
| MLA | Liu, Meiqing,et al."Peptide-au clusters induced tumor cells apoptosis via targeting glutathione peroxidase-1: the molecular dynamics assisted experimental studies".Scientific reports 7(2017):10. |
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来源：高能物理研究所
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