Synthesis, crystal structure and ptps inhibition of a zinc(ii) complex with n-(4-hydroxybenzyl)-l-serine
文献类型：期刊论文
| 作者 | Li Yan-Hong1,2; Lu Li-Ping1; Zhu Miao-Li1; Yuan Cai-Xia1; Feng Si-Si1; Gao Zeng-Qiang3 |
| 刊名 | Chinese journal of structural chemistry
 |
| 出版日期 | 2017-02-15 |
| 卷号 | 36期号:2页码:316-323 |
| 关键词 | Zinc(ii) complex N-(4-hydroxybenzyl)-l-serine Crystal structure Inhibitory activity Ptp1b Tcptp |
| ISSN号 | 0254-5861 |
| DOI | 10.14102/j.cnki.0254-5861.2011-1355 |
| 通讯作者 | Lu li-ping(luliping@sxu.edu.cn) ; Zhu miao-li(miaoli@sxu.edu.cn) |
| 英文摘要 | The reaction of the reduced schiff base hl (n-(4-hydroxybenzyl)-l-serine) with zn(ch3coo)(2)center dot 2h(2)o in aqueous solution afforded [zn(l)(2)]center dot 3h(2)o (i). the complex has been characterized by elemental analysis, ft-ir, powder x-ray diffraction, electrospray ionization mass spectrometry and single-crystal x-ray diffraction. complex i crystallizes in the orthorhombic system, space group p2(1)2(1)2(1), with a = 9.197(2), b = 10.445(2), c = 24.149(5) angstrom, v = 2319.8(8) angstrom(3), z = 4, c20h30n2o11zn, m-r = 539.83, d-c = 1.546 g.cm(3), mu = 1.122 mm(-1), f(000) = 1128, goof = 0.971, the final r = 0.0206 and wr = 0.0506 for 4346 observed reflections (i > 2 sigma(i)). in complex i, each zn(ii) ion coordinates with three carboxyl oxygen atoms and two amine nitrogen atoms from three l- anions, forming a distorted five-coordinated trigonal bipyramidal geometry. complex i exhibits a 1d wavy chain structure that is extended by hydrogen-bonding interactions to form a supramolecular network. the bioactivity of the complex as a potential ptps inhibitor in vitro was investigated, displaying potent inhibition against ptp1b (ic50, 0.24 mu m) and tcptp (ic50, 0.53 mu m) with a moderate selectivity. |
| WOS关键词 | PROTEIN-TYROSINE PHOSPHATASES ; SCHIFF-BASE ; OXOVANADIUM(IV) COMPLEXES ; DERIVATIVES ; POTENT ; ACID ; 1B |
| WOS研究方向 | Chemistry ; Crystallography |
| WOS类目 | Chemistry, Inorganic & Nuclear ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000397985700018 |
| 出版者 | CHINESE JOURNAL STRUCTURAL CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176686 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Lu Li-Ping; Zhu Miao-Li |
| 作者单位 | 1.Shanxi Univ, Educ Minist, Key Lab Chem Biol & Mol Engn, Inst Mol Sci, Taiyuan 030006, Peoples R China 2.Shanxi Med Univ, Fenyang Coll, Fenyang 032200, Shanxi, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Yan-Hong,Lu Li-Ping,Zhu Miao-Li,et al. Synthesis, crystal structure and ptps inhibition of a zinc(ii) complex with n-(4-hydroxybenzyl)-l-serine[J]. Chinese journal of structural chemistry,2017,36(2):316-323. |
| APA | Li Yan-Hong,Lu Li-Ping,Zhu Miao-Li,Yuan Cai-Xia,Feng Si-Si,&Gao Zeng-Qiang.(2017).Synthesis, crystal structure and ptps inhibition of a zinc(ii) complex with n-(4-hydroxybenzyl)-l-serine.Chinese journal of structural chemistry,36(2),316-323. |
| MLA | Li Yan-Hong,et al."Synthesis, crystal structure and ptps inhibition of a zinc(ii) complex with n-(4-hydroxybenzyl)-l-serine".Chinese journal of structural chemistry 36.2(2017):316-323. |
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