Interference of steroidogenesis by gold nanorod core/silver shell nanostructures: implications for reproductive toxicity of silver nanomaterials
文献类型：期刊论文
| 作者 | Jiang, Xiumei1,2,3; Wang, Liming1,2,3; Ji, Yinglu4,5; Tang, Jinglong1,2,3; Tian, Xin6; Cao, Mingjing1,2,3; Li, Jingxuan7; Bi, Shuying7; Wu, Xiaochun4,5; Chen, Chunying1,2,3 |
| 刊名 | Small
 |
| 出版日期 | 2017-03-14 |
| 卷号 | 13期号:10页码:13 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201602855 |
| 通讯作者 | Wu, xiaochun(wuxc@nanoctr.cn) ; Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | As a widely used nanomaterial in daily life, silver nanomaterials may cause great concern to female reproductive system as they are found to penetrate the bloodplacental barrier and gain access to the ovary. however, it is largely unknown about how silver nanomaterials influence ovarian physiology and functions such as hormone production. this study performs in vitro toxicology study of silver nanomaterials, focusing especially on cytotoxicity and steroidogenesis and explores their underlying mechanisms. this study exposes primary rat granulosa cells to gold nanorod core/silver shell nanostructures (au@ag nrs), and compares outcomes with cells exposed to gold nanorods. the au@ag nrs generate more reactive oxygen species and reduce mitochondrial membrane potential and less production of adenosine triphosphate. au@ag nrs promote steroidogenesis, including progesterone and estradiol, in a time-and dose-dependent manner. chemical reactivity and transformation of au@ag nrs are then studied by electron spin resonance spectroscopy and x-ray absorption near edge structure, which analyze the generation of free radical and intracellular silver species. results suggest that both particle-specific activity and intracellular silver ion release of au@ag nr contribute to the toxic response of granulosa cells. |
| WOS关键词 | FOLLICLE-STIMULATING-HORMONE ; OXIDATIVE STRESS ; IN-VITRO ; GRANULOSA-CELLS ; CELLULAR UPTAKE ; ALLOY NANOPARTICLES ; EMBRYO DEVELOPMENT ; APOPTOSIS ; CYTOTOXICITY ; MECHANISM |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000397616200014 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176687 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Xiaochun; Chen, Chunying |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing Key Lab Ambient Particles Hlth Effects &, Beijing 100190, Peoples R China 3.Inst High Energy Phys, Beijing 100190, Peoples R China 4.Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 5.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 6.US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA 7.Air Force PLA, Gen Hosp, Beijing 100142, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Xiumei,Wang, Liming,Ji, Yinglu,et al. Interference of steroidogenesis by gold nanorod core/silver shell nanostructures: implications for reproductive toxicity of silver nanomaterials[J]. Small,2017,13(10):13. |
| APA | Jiang, Xiumei.,Wang, Liming.,Ji, Yinglu.,Tang, Jinglong.,Tian, Xin.,...&Yin, Jun-Jie.(2017).Interference of steroidogenesis by gold nanorod core/silver shell nanostructures: implications for reproductive toxicity of silver nanomaterials.Small,13(10),13. |
| MLA | Jiang, Xiumei,et al."Interference of steroidogenesis by gold nanorod core/silver shell nanostructures: implications for reproductive toxicity of silver nanomaterials".Small 13.10(2017):13. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。