Mtor signaling in parkinson's disease
文献类型：期刊论文
| 作者 | Lan, Ai-ping; Chen, Jun; Zhao, Yuliang; Chai, Zhifang; Hu, Yi |
| 刊名 | Neuromolecular medicine
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 19期号:1页码:1-10 |
| ISSN号 | 1535-1084 |
| 关键词 | Mtor Parkinson's disease Apoptosis Alpha-synuclein Oxidative stress |
| DOI | 10.1007/s12017-016-8417-7 |
| 通讯作者 | Hu, yi(huyi@ihep.ac.cn) |
| 英文摘要 | As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mtor) emerges as a novel therapeutic target for parkinson's disease (pd). a growing body of research indicates that restoring perturbed mtor signaling in pd models can prevent neuronal cell death. nevertheless, molecular mechanisms underlying mtor-mediated effects in pd have not been fully understood yet. here, we review recent progress in characterizing the association of mtor signaling with pd risk factors and further discuss the potential roles of mtor in pd. |
| WOS关键词 | MUTANT ALPHA-SYNUCLEIN ; CENTRAL-NERVOUS-SYSTEM ; IN-VIVO MODELS ; OXIDATIVE STRESS ; DOPAMINERGIC-NEURONS ; MAMMALIAN TARGET ; NEURODEGENERATIVE DISEASES ; HYDROGEN-PEROXIDE ; PROTEIN-KINASE ; CELL-DEATH |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| 出版者 | HUMANA PRESS INC |
| WOS记录号 | WOS:000396029500001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176739 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Yi |
| 作者单位 | Chinese Acad Sci, Inst High Energy Phys, Multidisciplinary Res Div, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lan, Ai-ping,Chen, Jun,Zhao, Yuliang,et al. Mtor signaling in parkinson's disease[J]. Neuromolecular medicine,2017,19(1):1-10. |
| APA | Lan, Ai-ping,Chen, Jun,Zhao, Yuliang,Chai, Zhifang,&Hu, Yi.(2017).Mtor signaling in parkinson's disease.Neuromolecular medicine,19(1),1-10. |
| MLA | Lan, Ai-ping,et al."Mtor signaling in parkinson's disease".Neuromolecular medicine 19.1(2017):1-10. |
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来源：高能物理研究所
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