Graphene oxide nanosheets retard cellular migration via disruption of actin cytoskeleton
文献类型：期刊论文
| 作者 | Tian, Xin1; Yang, Zaixing1; Duan, Guangxin1; Wu, Anqing1; Gu, Zonglin1; Zhang, Leili2; Chen, Chunying1,3,4; Chai, Zhifang1,3,4; Ge, Cuicui1; Zhou, Ruhong1,2,5 |
| 刊名 | Small
 |
| 出版日期 | 2017-01-18 |
| 卷号 | 13期号:3页码:10 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201602133 |
| 通讯作者 | Ge, cuicui(ccge@suda.edu.cn) |
| 英文摘要 | Graphene and graphene-based nanomaterials are broadly used for various biomedical applications due to their unique physiochemical properties. however, how graphene-based nanomaterials interact with biological systems has not been thoroughly studied. this study shows that graphene oxide (go) nanosheets retard a549 lung carcinoma cell migration through nanosheet-mediated disruption of intracellular actin filaments. after go nanosheets treatment, a549 cells display slower migration and the structure of the intracellular actin filaments is dramatically changed. it is found that go nanosheets are capable of absorbing large amount of actin and changing the secondary structures of actin monomers. large-scale all-atom molecular dynamics simulations further reveal the interactions between go nanosheets and actin filaments at molecular details. go nanosheets can insert into the interstrand gap of actin tetramer (helical repeating unit of actin filament) and cause the separation of the tetramer which eventually leads to the disruption of actin filaments. these findings offer a novel mechanism of go nanosheet induced biophysical responses and provide more insights into their potential for biomedical applications. |
| WOS关键词 | CARBON NANOTUBES ; MOLECULAR-DYNAMICS ; FORCE-FIELDS ; CELLS ; WATER ; SIMULATIONS ; FILAMENTS ; CYTOTOXICITY ; TRANSITION ; INHIBITION |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000396567600003 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176788 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Ge, Cuicui |
| 作者单位 | 1.Soochow Univ, Collaborat Innovat Ctr, Radiat Med Jiangsu Higher Educ Inst, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China 2.IBM Corp, Thomas J Watson Res Ctr, Computat Biol Ctr, New York, NY 10598 USA 3.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, Beijing 100190, Peoples R China 5.Columbia Univ, Dept Chem, New York, NY 10027 USA |
| 推荐引用方式 GB/T 7714 | Tian, Xin,Yang, Zaixing,Duan, Guangxin,et al. Graphene oxide nanosheets retard cellular migration via disruption of actin cytoskeleton[J]. Small,2017,13(3):10. |
| APA | Tian, Xin.,Yang, Zaixing.,Duan, Guangxin.,Wu, Anqing.,Gu, Zonglin.,...&Zhou, Ruhong.(2017).Graphene oxide nanosheets retard cellular migration via disruption of actin cytoskeleton.Small,13(3),10. |
| MLA | Tian, Xin,et al."Graphene oxide nanosheets retard cellular migration via disruption of actin cytoskeleton".Small 13.3(2017):10. |
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来源：高能物理研究所
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