Zno nanoparticles act as supportive therapy in dss-induced ulcerative colitis in mice by maintaining gut homeostasis and activating nrf2 signaling
文献类型：期刊论文
| 作者 | Li, Jinquan1,2; Chen, Hanqing1; Wang, Bing1; Cai, Chengxu1,3; Yang, Xu2; Chai, Zhifang1; Feng, Weiyue1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2017-02-24 |
| 卷号 | 7页码:11 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep43126 |
| 通讯作者 | Yang, xu(yanxgu@mail.ccnu.edu.cn) ; Feng, weiyue(fengwy@ihep.ac.cn) |
| 英文摘要 | Inflammatory bowel diseases (ibd) are widespread inflammatory diseases that cause debilitating health problems including cancer. in this study, we show that zno nanoparticle (znonp) treatment has markedly dose-dependent effects on the remission of dextran sulfate sodium (dss)-induced ulcerative colitis in mice. we demonstrate the mechanism involves the antioxidant and anti-inflammatory abilities of znonps to suppress ros and malondialdehyde (mda) production; increase gsh level; suppress proinflammatory cytokines il-1 beta and tnf-beta and myeloperoxidase (mpo). the znonp treatment is able to activate the nrf2 pathway in the cellular antioxidant defense system. the novel finding is that znonp combined with mesalazine (5-asa) can enhance the therapeutic efficacy of 5-asa in the treatment of dss-induced colitis. lastly, we found that znonp treatment can restore the changes in special colonic bacteria of dss-mice while the drug 5-asa cannot. these results indicate that znonps can act as a medical additive for the therapy of ibd. |
| WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; SODIUM-INDUCED COLITIS ; NF-KAPPA-B ; INCREASED SUSCEPTIBILITY ; NRF2-DEFICIENT MICE ; OXIDATIVE STRESS ; MOUSE MODELS ; ZINC ; SULFATE ; PATHOGENESIS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000394647100001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176803 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yang, Xu; Feng, Weiyue |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan 430079, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jinquan,Chen, Hanqing,Wang, Bing,et al. Zno nanoparticles act as supportive therapy in dss-induced ulcerative colitis in mice by maintaining gut homeostasis and activating nrf2 signaling[J]. Scientific reports,2017,7:11. |
| APA | Li, Jinquan.,Chen, Hanqing.,Wang, Bing.,Cai, Chengxu.,Yang, Xu.,...&Feng, Weiyue.(2017).Zno nanoparticles act as supportive therapy in dss-induced ulcerative colitis in mice by maintaining gut homeostasis and activating nrf2 signaling.Scientific reports,7,11. |
| MLA | Li, Jinquan,et al."Zno nanoparticles act as supportive therapy in dss-induced ulcerative colitis in mice by maintaining gut homeostasis and activating nrf2 signaling".Scientific reports 7(2017):11. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。