Virus-inspired self-assembled nanofibers with aggregation-induced emission for highly efficient and visible gene delivery
文献类型：期刊论文
| 作者 | Zhang, Chunqiu1; Zhan, Tingbin2; Jin, Shubin1; Xue, Xiangdong1; Yang, Xiaolong1; Gong, Ningqiang1; Zhang, Jinchao3; Wang, Paul C.4,5; Tian, Jian-Hua2; Xing, Jinfeng2 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2017-02-08 |
| 卷号 | 9期号:5页码:4425-4432 |
| ISSN号 | 1944-8244 |
| 关键词 | Gene delivery Peptide Nanofibers Transfection Self-indicating |
| DOI | 10.1021/acsami.6b11536 |
| 通讯作者 | Xing, jinfeng(jinfengxing@tju.edu.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | High-efficiency gene transfer and suitably low cytotoxicity are the main goals of gene transfection systems based on nonviral vectors. in addition, it is desirable to track the gene transfer process in order to observe and explain the mechanism. herein, inspired by viral structures that are optimized for gene delivery, we designed a small-molecule gene vector (tr4) with aggregation-induced emission properties by capping a peptide containing four arginine residues with tetraphenylethene (tpe) and a lipophilic tail. this novel vector can self-assemble with plasmid dna to form nanofibers in solution with low cytotoxicity, high stability, and high transfection efficiency. pdna@tr4 complexes were able to transfect a variety of different cell lines, including stem cells. the self-assembly process induces bright fluorescence from tpe, which makes the nanofibers visible by confocal laser scanning microscopy (clsm). this allows us for the tracking of the gene delivery process. |
| WOS关键词 | CELL-PENETRATING PEPTIDES ; ARGININE-RICH PEPTIDES ; INTRACELLULAR DELIVERY ; THERAPY PROGRESS ; MAMMALIAN-CELLS ; SIRNA DELIVERY ; VECTORS ; SYSTEMS ; NANOPARTICLES ; PROSPECTS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000393848900019 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176818 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Xing, Jinfeng; Liang, Xing-Jie |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Tianjin Univ, Sch Chem Engn & Technol, 92,Weijin Rd, Tianjin 300072, Peoples R China 3.Hebei Univ, Chem Biol Key Lab Hebei Prov, Coll Chem & Environm Sci, Baoding 071002, Peoples R China 4.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA 5.Fu Jen Catholic Univ, Coll Sci & Engn, Taipei 24205, Taiwan |
| 推荐引用方式 GB/T 7714 | Zhang, Chunqiu,Zhan, Tingbin,Jin, Shubin,et al. Virus-inspired self-assembled nanofibers with aggregation-induced emission for highly efficient and visible gene delivery[J]. Acs applied materials & interfaces,2017,9(5):4425-4432. |
| APA | Zhang, Chunqiu.,Zhan, Tingbin.,Jin, Shubin.,Xue, Xiangdong.,Yang, Xiaolong.,...&Liang, Xing-Jie.(2017).Virus-inspired self-assembled nanofibers with aggregation-induced emission for highly efficient and visible gene delivery.Acs applied materials & interfaces,9(5),4425-4432. |
| MLA | Zhang, Chunqiu,et al."Virus-inspired self-assembled nanofibers with aggregation-induced emission for highly efficient and visible gene delivery".Acs applied materials & interfaces 9.5(2017):4425-4432. |
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来源：高能物理研究所
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