Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy
文献类型：期刊论文
| 作者 | Deng, Xiongwei1,2; Yin, Zhaoxia1; Lu, Jianqing2; Xia, Yang1; Shao, Leihou2; Hu, Qin1; Zhou, Zhixiang1; Zhang, Fang1; Zhou, Shaomei1; Wu, Yan2 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2017-02-01 |
| 卷号 | 9期号:4页码:3294-3305 |
| 关键词 | Nanohybrids Nir fluorescence "off-on" Tumor imaging Microrna modulation therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b11438 |
| 通讯作者 | Wu, yan(wuy@nanoctr.cn) ; Sheng, wang(shengwang@bjut.edu.cn) |
| 英文摘要 | Theranostic nanoparticles with combined imaging and therapy functions show great promise in cancer precision medicine. in this study, we constructed near-infrared (nir) "off-on" fluorescent nanohybrids (f-pnds) for synchronous tumor imaging and microrna (mirna) modulation therapy against esophageal cancer. nanodiamond clusters (nds) were first functionalized for protamine sulfate immobilization (pnds) on their surfaces via a noncovalent self-assembling approach and simultaneous encapsulation of nir emitting fluorescence dye cyanine 5 (cy-5) (f-pnds). tumor suppressor mirna-203 (mir-203) was then adsorbed onto the surface of f-pnds to form mir-203/f-pnds via electrostatic interactions. the size, morphology, photophysical and stability properties of mir-203/f-pnds were analyzed. we found that the nir fluorescence of mir-203/f-pnds could be activated to the "on" state in intracellular environment while remaining in the "off" state in extracellular or blood environment. furthermore, in vivo live imaging experiments showed that mir-203/f-pnds could be predominantly accumulated in tumor tissues and image the tumor sites 24 h postintravenous injection. in addition, intravenous and intratumoral injection of mir-203/f-pnds could efficiently inhibit tumor growth through down-regulation of the expressions of oncogenes ran and delta p63. our study indicated that mirna/f-pnds could serve as a promising theranostic platform for synchronous tumor imaging and mirna-based modulation therapy against cancer. |
| WOS关键词 | NEGATIVE BREAST-CANCER ; DRUG-DELIVERY ; IN-VIVO ; THERANOSTIC NANOPARTICLES ; GENE DELIVERY ; QUANTUM DOTS ; NANODIAMONDS ; CELLS ; RELEASE ; AGENTS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000393355900011 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176829 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Yan; Sheng, Wang |
| 作者单位 | 1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China 2.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Xiongwei,Yin, Zhaoxia,Lu, Jianqing,et al. Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy[J]. Acs applied materials & interfaces,2017,9(4):3294-3305. |
| APA | Deng, Xiongwei.,Yin, Zhaoxia.,Lu, Jianqing.,Xia, Yang.,Shao, Leihou.,...&Zeng, Yi.(2017).Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy.Acs applied materials & interfaces,9(4),3294-3305. |
| MLA | Deng, Xiongwei,et al."Two-step assembling of near-infrared "off-on" fluorescent nanohybrids for synchronous tumor imaging and microrna modulation-based therapy".Acs applied materials & interfaces 9.4(2017):3294-3305. |
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来源：高能物理研究所
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