Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway
文献类型：期刊论文
| 作者 | Zhang, Shaohan1; Chen, Shizhu1; Gao, Chunyue1; Jin, Yi1; Jia, Guang1; Li, Zhenhua1; Liu, Dandan1; Liang, Xingjie2; Yang, Xinjian1; Zhang, Jinchao1 |
| 刊名 | Science china-chemistry
 |
| 出版日期 | 2017 |
| 卷号 | 60期号:1页码:122-129 |
| 关键词 | Nayf4 nanoparticles Liver cells Apoptosis Oxidative stress Mitochondria damage |
| ISSN号 | 1674-7291 |
| DOI | 10.1007/s11426-016-0225-5 |
| 通讯作者 | Yang, xinjian(jianxinyang123@163.com) ; Zhang, jinchao(jczhang6970@163.com) |
| 英文摘要 | As lanthanide-doped sodium yttrium flouride (nayf4) nanoparticles have great potential in biomedical applications, their biosafety is important and has attracted significant attention. in the present work, three different sized nayf4:eu3+ nanoparticles have been prepared. liver brl 3a cell was used as a cell model to evaluate their biological effects. cell viability and apoptosis assays were used to confirm the cytotoxicity induced by nayf4:eu3+ nps. apart from the elevated malondialdehyde (mda), the decrease of superoxide dismutase (sod), glutathione peroxidase (gsh-px) and catalase (cat) activity indicated reactive oxygen species (ros) generation, which were associated with oxidative damage. the decrease of mitochondrial membrane potential (mmp) value demonstrated the occurrence of mitochondria damage. then, release of cytochrome c from mitochondria and activation of caspase-3 confirmed that nayf4:eu3+ nps induced apoptosis was mitochondria damage-dependent. |
| WOS关键词 | LANTHANIDE-DOPED NANOPARTICLES ; CERIUM OXIDE NANOPARTICLES ; OXIDATIVE STRESS ; CYTOCHROME-C ; UPCONVERTING NANOCRYSTALS ; CYTOTOXICITY ; SIZE ; BIODISTRIBUTION ; INDUCTION ; AUTOPHAGY |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000392085900014 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176851 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yang, Xinjian; Zhang, Jinchao |
| 作者单位 | 1.Hebei Univ, Coll Chem & Environm Sci, Key Lab Med Chem & Mol Diag, Minist Educ,Chem Biol Key Lab Hebei Prov, Baoding 071002, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shaohan,Chen, Shizhu,Gao, Chunyue,et al. Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway[J]. Science china-chemistry,2017,60(1):122-129. |
| APA | Zhang, Shaohan.,Chen, Shizhu.,Gao, Chunyue.,Jin, Yi.,Jia, Guang.,...&Zhang, Jinchao.(2017).Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway.Science china-chemistry,60(1),122-129. |
| MLA | Zhang, Shaohan,et al."Apoptosis induced by nayf4:eu3+ nanoparticles in liver cells via mitochondria damage dependent pathway".Science china-chemistry 60.1(2017):122-129. |
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