Metallofullerenol inhibits cellular iron uptake by inducing transferrin tetramerization
文献类型：期刊论文
| 作者 | Li, Jinxia1; Xing, Xueqing2; Sun, Baoyun1; Zhao, Yuliang1,3; Wu, Zhonghua2 |
| 刊名 | Chemistry-an asian journal
 |
| 出版日期 | 2017-10-18 |
| 卷号 | 12期号:20页码:2646-2651 |
| 关键词 | Cancer therapy Iron uptake Nanomedicine Small-angle x-ray scattering Transferrin |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.201700910 |
| 通讯作者 | Zhao, yuliang(zhaoyuliang@ihep.ac.cn) ; Wu, zhonghua(wuzh@ihep.ac.cn) |
| 英文摘要 | Herein, a549 tumor cell proliferation was confirmed to be positively dependent on the concentration of fe3+ or transferrin (tf). gd@c-82(oh)(22) or c-60(oh)(22) effectively inhibited the iron uptake and the subsequent proliferation of a549 cells. the conformational changes of tf mixed with fecl3, gdcl3, c-60(oh)(22) or gd@c-82(oh)(22) were obtained by saxs. the results demonstrate that tf homodimers can be decomposed into monomers in the presence of fecl3, gdcl3 or c-60(oh)(22), but associated into tetramers in the presence of gd@c-82(oh)(22). the larger change of saxs shapes between tf+c-60(oh)(22) and tf+fecl3 implies that c-60(oh)(22) is bound to tf, blocking the iron-binding site. the larger deviation of the saxs shape from a possible crystal structure of tf tetramer implies that gd@c-82(oh)(22) is bound to the tf tetramer, thus disturbing iron transport. this study well explains the inhibition mechanism of gd@c-82(oh)(22) and c-60(oh)(22) on the iron uptake and the proliferation of a549 tumor cells and highlights the specific interactions of a nanomedicine with the target biomolecules in cancer therapy. |
| WOS关键词 | SMALL-ANGLE SCATTERING ; X-RAY-SCATTERING ; BIOLOGICAL MACROMOLECULES ; FULLERENE DERIVATIVES ; NANOPARTICLES ; CANCER ; GD-AT-C-82(OH)(22) ; ACTIVATION ; PROLIFERATION ; NANOMEDICINE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000413354300003 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176869 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, Yuliang; Wu, Zhonghua |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Beijing Synchrotron Radiat Facil, Inst High Energy Phys, Beijing 100049, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jinxia,Xing, Xueqing,Sun, Baoyun,et al. Metallofullerenol inhibits cellular iron uptake by inducing transferrin tetramerization[J]. Chemistry-an asian journal,2017,12(20):2646-2651. |
| APA | Li, Jinxia,Xing, Xueqing,Sun, Baoyun,Zhao, Yuliang,&Wu, Zhonghua.(2017).Metallofullerenol inhibits cellular iron uptake by inducing transferrin tetramerization.Chemistry-an asian journal,12(20),2646-2651. |
| MLA | Li, Jinxia,et al."Metallofullerenol inhibits cellular iron uptake by inducing transferrin tetramerization".Chemistry-an asian journal 12.20(2017):2646-2651. |
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