Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim
文献类型：期刊论文
| 作者 | Li, Yao1; Ren, Meng1; Wang, Xiaoqun2; Cui, Xingxing1; Zhao, Hongmei1; Zhao, Chuanrong3,4; Zhou, Jing3,4; Guo, Yanan5; Hu, Yi6; Yan, Chen5 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2017-11-14 |
| 卷号 | 7页码:11 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-15672-3 |
| 通讯作者 | Hu, yi(huyi@ihep.ac.cn) ; Wang, jing(wangjing@ibms.pumc.edu.cn) |
| 英文摘要 | Endothelial cell apoptosis induced by oxidative stress is an early event in the development of atherosclerosis. several antioxidant enzymes which can cope with oxidative stress are up-regulated by the anti-atherogenic laminar blood flow often seen in straight or unbranched regions of blood vessels. however, the molecular mechanism responsible for flow-induced beneficial effects is incompletely understood. here we report the role of glutaredoxin 1 (grx1), an antioxidant enzyme, in flow-mediated protective effect in endothelial cells. specifically, we found that grx1 is markedly up-regulated by the steady laminar flow. increasing grx1 reduces the pro-apoptotic protein bim expression through regulating akt-foxo1 signaling and also attenuates h2o2-induced bim activation via inhibiting jnk phosphorylation, subsequently preventing the apoptosis of endothelial cells. grx1 knockdown abolishes the inhibitory effect of steady laminar flow on bim. the inhibitory effect of grx1 on bim is dependent on grx1's thioltransferase activity. these findings indicate that grx1 induction plays a key role in mediating the protective effect of laminar blood flow and suggest that grx1 may be a potential therapeutic target for atherosclerosis. |
| WOS关键词 | BCL-2 PROTEIN FAMILY ; RED-BLOOD-CELLS ; BAX ACTIVATION ; UV-IRRADIATION ; DEATH PATHWAY ; AKT ; JNK ; GLUTATHIONYLATION ; PHOSPHORYLATION ; IDENTIFICATION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000415166000035 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176871 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Yi; Wang, Jing |
| 作者单位 | 1.Chinese Acad Med Sci, State Key Lab Med Mol Biol, Dept Pathophysiol, Inst Basic Med Sci,Sch Basic Med,Peking Union Med, Beijing 100005, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Cardiol, Sch Med, Shanghai 200025, Peoples R China 3.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China 4.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China 5.Univ Rochester, Sch Med & Dent, 4Aab Cardiovasc Res Inst, Rochester, NY 14642 USA 6.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Inst High Energy Phys, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yao,Ren, Meng,Wang, Xiaoqun,et al. Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim[J]. Scientific reports,2017,7:11. |
| APA | Li, Yao.,Ren, Meng.,Wang, Xiaoqun.,Cui, Xingxing.,Zhao, Hongmei.,...&Wang, Jing.(2017).Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim.Scientific reports,7,11. |
| MLA | Li, Yao,et al."Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim".Scientific reports 7(2017):11. |
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