中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim

文献类型:期刊论文

作者Li, Yao1; Ren, Meng1; Wang, Xiaoqun2; Cui, Xingxing1; Zhao, Hongmei1; Zhao, Chuanrong3,4; Zhou, Jing3,4; Guo, Yanan5; Hu, Yi6; Yan, Chen5
刊名Scientific reports
出版日期2017-11-14
卷号7页码:11
ISSN号2045-2322
DOI10.1038/s41598-017-15672-3
通讯作者Hu, yi(huyi@ihep.ac.cn) ; Wang, jing(wangjing@ibms.pumc.edu.cn)
英文摘要Endothelial cell apoptosis induced by oxidative stress is an early event in the development of atherosclerosis. several antioxidant enzymes which can cope with oxidative stress are up-regulated by the anti-atherogenic laminar blood flow often seen in straight or unbranched regions of blood vessels. however, the molecular mechanism responsible for flow-induced beneficial effects is incompletely understood. here we report the role of glutaredoxin 1 (grx1), an antioxidant enzyme, in flow-mediated protective effect in endothelial cells. specifically, we found that grx1 is markedly up-regulated by the steady laminar flow. increasing grx1 reduces the pro-apoptotic protein bim expression through regulating akt-foxo1 signaling and also attenuates h2o2-induced bim activation via inhibiting jnk phosphorylation, subsequently preventing the apoptosis of endothelial cells. grx1 knockdown abolishes the inhibitory effect of steady laminar flow on bim. the inhibitory effect of grx1 on bim is dependent on grx1's thioltransferase activity. these findings indicate that grx1 induction plays a key role in mediating the protective effect of laminar blood flow and suggest that grx1 may be a potential therapeutic target for atherosclerosis.
WOS关键词BCL-2 PROTEIN FAMILY ; RED-BLOOD-CELLS ; BAX ACTIVATION ; UV-IRRADIATION ; DEATH PATHWAY ; AKT ; JNK ; GLUTATHIONYLATION ; PHOSPHORYLATION ; IDENTIFICATION
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
语种英语
WOS记录号WOS:000415166000035
出版者NATURE PUBLISHING GROUP
URI标识http://www.irgrid.ac.cn/handle/1471x/2176871
专题高能物理研究所
通讯作者Hu, Yi; Wang, Jing
作者单位1.Chinese Acad Med Sci, State Key Lab Med Mol Biol, Dept Pathophysiol, Inst Basic Med Sci,Sch Basic Med,Peking Union Med, Beijing 100005, Peoples R China
2.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Cardiol, Sch Med, Shanghai 200025, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China
4.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
5.Univ Rochester, Sch Med & Dent, 4Aab Cardiovasc Res Inst, Rochester, NY 14642 USA
6.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Inst High Energy Phys, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Li, Yao,Ren, Meng,Wang, Xiaoqun,et al. Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim[J]. Scientific reports,2017,7:11.
APA Li, Yao.,Ren, Meng.,Wang, Xiaoqun.,Cui, Xingxing.,Zhao, Hongmei.,...&Wang, Jing.(2017).Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim.Scientific reports,7,11.
MLA Li, Yao,et al."Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting bim".Scientific reports 7(2017):11.

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