Two mtor inhibitors, rapamycin and torin 1, differentially regulate iron-induced generation of mitochondrial ros
文献类型：期刊论文
| 作者 | Huang, Hui1,2; Chen, Jun1,2; Lu, Huiru1; Zhou, Mengxue1,2; Chai, Zhifang1,2; Hu, Yi1,2 |
| 刊名 | Biometals
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 30期号:6页码:975-980 |
| ISSN号 | 0966-0844 |
| 关键词 | Mtor Rapamycin Torin 1 Ros |
| DOI | 10.1007/s10534-017-0059-1 |
| 通讯作者 | Hu, yi(huyi@ihep.ac.cn) |
| 英文摘要 | It is generally believed that gene-environment interaction may contribute to neurodegeneration. of particular note is that iron overload may be one of the risk factors for neurodegeneration. however, the mechanisms underlying iron-associated neurotoxicity are not fully understood. here we explored the effects of mechanistic target of rapamycin (mtor) inhibition in iron-stressed human neuroblastoma cells. two mtor inhibitors, rapamycin and torin 1, had similar effects in cells exposed to a relatively low concentration of iron. at a higher concentration of iron, torin 1, instead of rapamycin, could further aggravate iron-induced cytotoxicity, and mitochondrial ros levels were significantly higher in torin 1-treated cells. these results suggest that mtor inhibition may not be able to alleviate iron-induced neurotoxicity. |
| WOS关键词 | PARKINSONS-DISEASE ; DIETARY-INTAKE ; SH-SY5Y CELLS ; RISK-FACTORS ; NEUROTOXICITY ; AUTOPHAGY ; COPPER |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000415283000012 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176915 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Yi |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Inst High Energy Phys, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Hui,Chen, Jun,Lu, Huiru,et al. Two mtor inhibitors, rapamycin and torin 1, differentially regulate iron-induced generation of mitochondrial ros[J]. Biometals,2017,30(6):975-980. |
| APA | Huang, Hui,Chen, Jun,Lu, Huiru,Zhou, Mengxue,Chai, Zhifang,&Hu, Yi.(2017).Two mtor inhibitors, rapamycin and torin 1, differentially regulate iron-induced generation of mitochondrial ros.Biometals,30(6),975-980. |
| MLA | Huang, Hui,et al."Two mtor inhibitors, rapamycin and torin 1, differentially regulate iron-induced generation of mitochondrial ros".Biometals 30.6(2017):975-980. |
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来源：高能物理研究所
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