Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy
文献类型：期刊论文
| 作者 | Zhang, Lingmin1,2; Wang, Peng1,2; Zheng, Wenfu1,2; Jiang, Xingyu1,2,3 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2017-08-28 |
| 卷号 | 5期号:32页码:6601-6607 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c7tb01105a |
| 通讯作者 | Zheng, wenfu() ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | We present novel hollow carbon nanospheres (hcns) for targeted breast cancer therapy. the hcns have a 40 nm-cavity for drugs loading, and the surface is covered with "natural'' primary amine without any exogenous modification, equipped to conjugate with functional biomolecules. after modification with anti-her2 antibody and loading of doxorubicin (dox) to the hcns, the her2@hcns/dox can specifically access her2-positive breast cancer cells and significantly suppress the cells in vitro, causing similar to 60% reduction of the volume of the her2-positive tumours in vivo. the hcns show great promise to become a multifunctional carrier in the field of high-loading capacity drug delivery for cancer therapy. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; GRAPHENE OXIDE ; DRUG-DELIVERY ; RELEASE ; GENE ; TRASTUZUMAB ; CELLS ; ERBB2 |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000407684800016 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176982 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zheng, Wenfu; Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lingmin,Wang, Peng,Zheng, Wenfu,et al. Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy[J]. Journal of materials chemistry b,2017,5(32):6601-6607. |
| APA | Zhang, Lingmin,Wang, Peng,Zheng, Wenfu,&Jiang, Xingyu.(2017).Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy.Journal of materials chemistry b,5(32),6601-6607. |
| MLA | Zhang, Lingmin,et al."Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy".Journal of materials chemistry b 5.32(2017):6601-6607. |
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来源：高能物理研究所
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