Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation
文献类型：期刊论文
| 作者 | Geng, Huan1,2; Chang, Ya-Nan2; Bai, Xue2,3; Liu, Shuitao1; Yuan, Qing2,3; Gu, Weihong2,3; Li, Juan2; Chen, Kui2; Xing, Gengyan1; Xing, Gengmei2 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2017-09-14 |
| 卷号 | 9期号:34页码:12516-12523 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c7nr04365a |
| 通讯作者 | Xing, gengyan() ; Xing, gengmei(xinggm@ihep.ac.cn) |
| 英文摘要 | Bone health requires regulation of homeostatic equilibrium between osteoblasts and osteoclasts. the over-activation of osteoclasts can disrupt bone metabolism, resulting in osteoporosis and other boneloss diseases. fullerenol, a polyhydroxy derivative of fullerene, exhibits excellent biocompatibility. here we show that fullerenol nanoparticles exert two functions: inhibition of osteoclastic differentiation and blockage of pre-osteoclast fusion to restructure osteoclast maturation and function. experimentally, the nanoparticles reduced pre-osteoclast migration and inhibited ruffled border formation to block their maturation. in addition, fullerenol dose-dependently restricted the differentiation of bone marrow macrophage cells (bmms) to form osteoclasts following treatment with macrophage colony-stimulating factor (m-csf) and receptor activator of nuclear factor (nf)-kappa b (rankl) to activate nf-kappa b and mitogen activating protein kinase (mapk) signaling pathways. it is possible that the very small size of fullerenol allows it to directly cross the cellular membrane to access the cytoplasm and regulate osteoclastogenesis from bmms. our results suggest that fullerenol could be used to treat bone-loss diseases such as osteoporosis. |
| WOS关键词 | ACTIN ; BONE ; MECHANISMS ; FUSION ; ORGANIZATION ; ACTIVATION ; PRECURSORS ; MIGRATION ; PODOSOME ; DISEASE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000409215300035 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177010 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Xing, Gengyan; Xing, Gengmei |
| 作者单位 | 1.Gen Hosp Chinese Peoples Armed Police Forces, Dept Orthoped, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Huan,Chang, Ya-Nan,Bai, Xue,et al. Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation[J]. Nanoscale,2017,9(34):12516-12523. |
| APA | Geng, Huan.,Chang, Ya-Nan.,Bai, Xue.,Liu, Shuitao.,Yuan, Qing.,...&Xing, Gengmei.(2017).Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation.Nanoscale,9(34),12516-12523. |
| MLA | Geng, Huan,et al."Fullerenol nanoparticles suppress rankl-induced osteoclastogenesis by inhibiting differentiation and maturation".Nanoscale 9.34(2017):12516-12523. |
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来源：高能物理研究所
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