Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells
文献类型：期刊论文
| 作者 | Zhang, Xiao1,2,3,4; Guo, Zhao1,2,4; Liu, Jing1,2,3,4; Tian, Gan5,6; Chen, Kui1,2,4; Yu, Shicang5,6; Gu, Zhanjun1,2,4 |
| 刊名 | Science bulletin
 |
| 出版日期 | 2017-07-30 |
| 卷号 | 62期号:14页码:985-996 |
| 关键词 | Upconversion nanoparticles Nitric oxide Cancer stem-like cells Synergistic effect of no and chemotherapy Drug resistance reversal |
| ISSN号 | 2095-9273 |
| DOI | 10.1016/j.scib.2017.06.010 |
| 通讯作者 | Gu, zhanjun(zjgu@ihep.ac.cn) |
| 英文摘要 | Near infrared (nir) light-driven nitric oxide (no) release nano-platform based on upconversion nanoparticles (ucnps) and light sensitive no precursor roussin's black salt (rbs) was fabricated to generate no upon 808 nm irradiation. the application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. the combination of ucnps and rbs could realize the on-demand release of no at desired time and location by simply controlling the output of nir laser. cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells (cscs) rather than non-cscs. therefore, a synergistic cancer therapy strategy to eradicate both cscs and non-cscs simultaneously was developed. traditional chemo-drug could inhibit non-cscs but has low killing efficiency in cscs. however, we found that the combination of no and chemotherapy could efficiently inhibit cscs in bulk cells, including inhibiting mammosphere formation ability, decreasing cd44(+)/cd24 subpopulation and reducing tumorigenic ability. the mechanism studies confirmed that no could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in cscs. this ucnps-based platform may provide a new combinatorial strategy of no and chemotherapy to improve cancer treatment. (c) 2017 science china press. published by elsevier b.v. and science china press. all rights reserved. |
| WOS关键词 | IN-VITRO PROPAGATION ; DRUG-RESISTANCE ; CO-DELIVERY ; DOXORUBICIN ; NO ; NANOCOMPOSITES ; INHIBITION ; AGENTS ; CD44 ; ACID |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000409086700007 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177014 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gu, Zhanjun |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Third Mil Med Univ, Inst Pathol, Southwest Hosp, Chongqing 400038, Peoples R China 6.Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, Chongqing 400038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiao,Guo, Zhao,Liu, Jing,et al. Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells[J]. Science bulletin,2017,62(14):985-996. |
| APA | Zhang, Xiao.,Guo, Zhao.,Liu, Jing.,Tian, Gan.,Chen, Kui.,...&Gu, Zhanjun.(2017).Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells.Science bulletin,62(14),985-996. |
| MLA | Zhang, Xiao,et al."Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells".Science bulletin 62.14(2017):985-996. |
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来源：高能物理研究所
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